Reactome | Ifngr2 [plasma membrane]

Ifngr2 [plasma membrane]

Stable Identifier

R-MMU-629620

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

IFNGR2, Q63953

Locations in the PathwayBrowser

Expand all

Immune System (Mus musculus)

- Cytokine Signaling in Immune system (Mus musculus)
  - Interferon Signaling (Mus musculus)
    - Interferon gamma signaling (Mus musculus)
      - Binding of STAT1 to p-IFNGR1 (Mus musculus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        Ifngr2 [plasma membrane] (Mus musculus)
        
        STAT1 bound to p-IFNGR1 [plasma membrane] (Mus musculus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        Ifngr2 [plasma membrane] (Mus musculus)
      - IFNG dimer binds IFNGR (Mus musculus)
        
        IFNG:IFNGR1:JAK1:IFNGR2:JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR1:JAK1:INFGR2:JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:JAK2 [plasma membrane] (Mus musculus)
        
        Ifngr2 [plasma membrane] (Mus musculus)
        
        IFNGR1:JAK1:INFGR2:JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:JAK2 [plasma membrane] (Mus musculus)
        
        Ifngr2 [plasma membrane] (Mus musculus)
      - IFNG signaling activates MAPKs (Mus musculus)
        
        Activated JAK1 binds RAF1 (Mus musculus)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR complex with p-JAK [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        Ifngr2 [plasma membrane] (Mus musculus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:RAF1 [plasma membrane] (Mus musculus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        Ifngr2 [plasma membrane] (Mus musculus)
        
        JAK1-activated RAF1 phosphorylates MAPKs (Mus musculus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:p-Y-RAF1 [plasma membrane] (Mus musculus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        Ifngr2 [plasma membrane] (Mus musculus)
        
        JAK1-mediated phosphorylation of RAF1 (Mus musculus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:RAF1 [plasma membrane] (Mus musculus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        Ifngr2 [plasma membrane] (Mus musculus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:p-Y-RAF1 [plasma membrane] (Mus musculus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        Ifngr2 [plasma membrane] (Mus musculus)
      - IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Mus musculus)
        
        IFNGR1:JAK1:INFGR2:JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:JAK2 [plasma membrane] (Mus musculus)
        
        Ifngr2 [plasma membrane] (Mus musculus)
        
        IFNGR1:JAK1:INFGR2:JAK2:JAK1,2 inhibitors [plasma membrane] (Mus musculus)
        
        IFNGR1:JAK1:INFGR2:JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:JAK2 [plasma membrane] (Mus musculus)
        
        Ifngr2 [plasma membrane] (Mus musculus)
      - JAK2-activated MAPKs phosphorylate YBX1 (Mus musculus)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR complex with p-JAK [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        Ifngr2 [plasma membrane] (Mus musculus)
      - Phosphorylation of IFNGR1 by JAK kinases (Mus musculus)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR complex with p-JAK [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        Ifngr2 [plasma membrane] (Mus musculus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        Ifngr2 [plasma membrane] (Mus musculus)
      - Phosphorylation of JAK2 (Mus musculus)
        
        IFNG:IFNGR1:JAK1:IFNGR2:JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR1:JAK1:INFGR2:JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:JAK2 [plasma membrane] (Mus musculus)
        
        Ifngr2 [plasma membrane] (Mus musculus)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR complex with p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        Ifngr2 [plasma membrane] (Mus musculus)
      - Phosphorylation of STAT1 at Ser727 (Mus musculus)
        
        p-STAT1 dimer bound to p-IFNGR1 [plasma membrane] (Mus musculus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        Ifngr2 [plasma membrane] (Mus musculus)
        
        p-STAT1(Y701) bound to p-IFNGR1 [plasma membrane] (Mus musculus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        Ifngr2 [plasma membrane] (Mus musculus)
      - Phosphorylation of STAT1 by JAK kinases (Mus musculus)
        
        STAT1 bound to p-IFNGR1 [plasma membrane] (Mus musculus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        Ifngr2 [plasma membrane] (Mus musculus)
        
        p-STAT1(Y701) bound to p-IFNGR1 [plasma membrane] (Mus musculus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        Ifngr2 [plasma membrane] (Mus musculus)
      - Regulation of IFNG signaling (Mus musculus)
        
        SOCS-1 and SOCS-3 binds to p-JAK2 (Mus musculus)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR complex with p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        Ifngr2 [plasma membrane] (Mus musculus)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Mus musculus)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR complex with p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        Ifngr2 [plasma membrane] (Mus musculus)
      - Release of STAT1 dimer from active receptor unit (Mus musculus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        Ifngr2 [plasma membrane] (Mus musculus)
        
        p-STAT1 dimer bound to p-IFNGR1 [plasma membrane] (Mus musculus)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        Ifngr2 [plasma membrane] (Mus musculus)
      - Transphosphorylation of JAK1 (Mus musculus)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR complex with p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        Ifngr2 [plasma membrane] (Mus musculus)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Mus musculus)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR complex with p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        Ifngr2 [plasma membrane] (Mus musculus)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        IFNGR complex with p-JAK [plasma membrane] (Mus musculus)
        
        IFNGR2:p-JAK2 [plasma membrane] (Mus musculus)
        
        Ifngr2 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:Q63953

Gene Names

Ifngr2

Reference Genes

BioGPS Gene:15980 Ifngr2

ENSEMBL:ENSMUSG00000022965

ENSEMBL:ENSMUSG00000022965.9 Ifngr2

KEGG Gene (Mus musculus):15980 Ifngr2

Monarch:15980 Ifngr2

NCBI Gene:15980 Ifngr2

UCSC:Q63953 Ifngr2

Reference Transcript

RefSeq:NM_008338.3 Ifngr2

Other Identifiers

10436865

115695_r_at

1423557_at

1423558_at

15980

160694_at

17327084

4449075

4720627

4960747

5004881

5060060

5098854

5148177

5148229

5389367

5510304

5611066

A_51_P196687

A_52_P471395

GE117988

GO:0001774

GO:0002376

GO:0004896

GO:0004906

GO:0005515

GO:0005886

GO:0006954

GO:0016020

GO:0019221

GO:0023052

GO:0038196

GO:0051607

GO:0060089

GO:0060333

GO:0098542

ILMN_1258300

ILMN_2592700

ILMN_2592709

ILMN_2784272

Msa.3298.0_at

mMC005805

mMC025822

Participates

as a component of

Inferred From

IFNGR2 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_032364.1

Ensembl

ENSMUST00000023687, ENSMUSP00000023687, ENSMUSG00000022965

MGI

107654

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