Hoxb1 maintains activation of Hoxb1 chromatin

Stable Identifier
Reaction [omitted]
Mus musculus
SVG |   | PPTX  | SBGN
Hoxb1 maintains activation of Hoxb1 chromatin

In mouse embryos (Ferretti et al. 2000) and embryonal carcinoma cells (Ferretti et al. 2000, Ferretti et al. 2005), Hoxb1 binds with the Pbx1:Pknox1 (Pbx1:Prep1) heterodimer and Meis1 (Huang et al. 2005) at the promoter of the Hoxb1 gene to maintain expression after initial activation of Hoxb1 by retinoic acid signaling. Binding of SOX:OCT heterodimers to the mouse HOXB1 promoter also appears to positively regulate HOXB1 transcription (Di Rocco et al. 2001).

Literature References
PubMed ID Title Journal Year
15654074 MEIS C termini harbor transcriptional activation domains that respond to cell signaling

Huang, H, Rastegar, M, Bodner, C, Goh, SL, Rambaldi, I, Featherstone, M

J. Biol. Chem. 2005
16166636 Hoxb1 enhancer and control of rhombomere 4 expression: complex interplay between PREP1-PBX1-HOXB1 binding sites

Ferretti, E, Cambronero, F, Tümpel, S, Longobardi, E, Wiedemann, LM, Blasi, F, Krumlauf, R

Mol. Cell. Biol. 2005
10654609 Segmental expression of Hoxb2 in r4 requires two separate sites that integrate cooperative interactions between Prep1, Pbx and Hox proteins

Ferretti, E, Marshall, H, Pöpperl, H, Maconochie, M, Krumlauf, R, Blasi, F

Development 2000
11278854 The recruitment of SOX/OCT complexes and the differential activity of HOXA1 and HOXB1 modulate the Hoxb1 auto-regulatory enhancer function

Di Rocco, G, Gavalas, A, Pöpperl, H, Krumlauf, R, Mavilio, F, Zappavigna, V

J. Biol. Chem. 2001
Orthologous Events