Rora, Ep300 bind Srebf1 gene

Stable Identifier
R-MMU-5663291
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Rora, Ep300 bind Srebf1 gene
Rora binds the RRE DNA element and recruits the coactivators Pgc-1alpha (Ppargc1a) and p300 (Ep300, a histone acetyltransferase). Rora binds the promoter of the Srebf1 gene and enhances transcription.
Literature References
PubMed ID Title Journal Year
18441015 The orphan nuclear receptor, RORalpha, regulates gene expression that controls lipid metabolism: staggerer (SG/SG) mice are resistant to diet-induced obesity

Wang, SC, Lau, P, Fitzsimmons, RL, Raichur, S, Lechtken, A, Muscat, GE

J Biol Chem 2008
Participants
Input
Output
Orthologous Events
RORA, EP300 bind SREBF1 gene (Homo sapiens)
Authored
May, B  (2015-01-17)
Reviewed
Delaunay, F  (2012-01-28)
Created
May, B  (2015-01-17)
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