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Smurf2 [cytosol]
Stable Identifier
R-MMU-5632468
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Class I MHC mediated antigen processing & presentation (Mus musculus)
Antigen processing: Ubiquitination & Proteasome degradation (Mus musculus)
Interaction of E3 with substrate and E2-Ub complex (Mus musculus)
Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
Smurf2 [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
Smurf2 [cytosol] (Mus musculus)
Polyubiquitination of substrate (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
Smurf2 [cytosol] (Mus musculus)
E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
Smurf2 [cytosol] (Mus musculus)
E3:Ub:substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
Smurf2 [cytosol] (Mus musculus)
Release of E3 from polyubiquitinated substrate (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
Smurf2 [cytosol] (Mus musculus)
E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
Smurf2 [cytosol] (Mus musculus)
Transfer of Ub from E2 to substrate and release of E2 (Mus musculus)
Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
Smurf2 [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
Smurf2 [cytosol] (Mus musculus)
E3:Ub:substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
Smurf2 [cytosol] (Mus musculus)
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Deubiquitination (Mus musculus)
Ub-specific processing proteases (Mus musculus)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Mus musculus)
USP15:SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Mus musculus)
SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Mus musculus)
SMAD7:SMURF2:TGFBR1 [plasma membrane] (Mus musculus)
SMAD7:SMURF2 [cytosol] (Mus musculus)
Smurf2 [cytosol] (Mus musculus)
USP15:Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Mus musculus)
Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Mus musculus)
SMAD7:SMURF2:Ub-TGFBR1 [plasma membrane] (Mus musculus)
Smurf2 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by Hedgehog (Mus musculus)
Hedgehog 'on' state (Mus musculus)
SMURF1/2 dissociates from ub-PTCH1 (Mus musculus)
SMURF [cytosol] (Mus musculus)
Smurf2 [cytosol] (Mus musculus)
ub-PTCH1:SMURF [ciliary membrane] (Mus musculus)
SMURF [cytosol] (Mus musculus)
Smurf2 [cytosol] (Mus musculus)
Signaling by TGFB family members (Mus musculus)
Signaling by BMP (Mus musculus)
I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Mus musculus)
BMP:p-BMPR:I-SMAD:SMURF [plasma membrane] (Mus musculus)
I-SMAD:SMURF [cytosol] (Mus musculus)
SMURF [cytosol] (Mus musculus)
Smurf2 [cytosol] (Mus musculus)
I-SMAD:SMURF [cytosol] (Mus musculus)
SMURF [cytosol] (Mus musculus)
Smurf2 [cytosol] (Mus musculus)
Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Mus musculus)
SMURF [cytosol] (Mus musculus)
Smurf2 [cytosol] (Mus musculus)
Signaling by TGF-beta Receptor Complex (Mus musculus)
TGF-beta receptor signaling activates SMADs (Mus musculus)
Downregulation of TGF-beta receptor signaling (Mus musculus)
SMURF2 binds SMAD2 (Mus musculus)
SMAD2:SMURF2 [cytosol] (Mus musculus)
Smurf2 [cytosol] (Mus musculus)
Smurf2 [cytosol] (Mus musculus)
SMURF2 ubiquitinates SMAD2 (Mus musculus)
SMAD2:SMURF2 [cytosol] (Mus musculus)
Smurf2 [cytosol] (Mus musculus)
Smurf2 [cytosol] (Mus musculus)
Signaling by WNT (Mus musculus)
Beta-catenin independent WNT signaling (Mus musculus)
PCP/CE pathway (Mus musculus)
Asymmetric localization of PCP proteins (Mus musculus)
SMURF1/2 are recruited to the DVL2:PARD6A complex (Mus musculus)
PARD6A:pp-DVL2:SMURF [plasma membrane] (Mus musculus)
SMURF [cytosol] (Mus musculus)
Smurf2 [cytosol] (Mus musculus)
SMURF [cytosol] (Mus musculus)
Smurf2 [cytosol] (Mus musculus)
SMURF1/2 ubiquitinates PRICKLE1 (Mus musculus)
PARD6A:pp-DVL2:SMURF [plasma membrane] (Mus musculus)
SMURF [cytosol] (Mus musculus)
Smurf2 [cytosol] (Mus musculus)
SMURF [cytosol] (Mus musculus)
Smurf2 [cytosol] (Mus musculus)
TCF dependent signaling in response to WNT (Mus musculus)
Degradation of AXIN (Mus musculus)
AXIN is ubiquitinated by SMURF2 (Mus musculus)
AXIN:SMURF2 [cytosol] (Mus musculus)
Smurf2 [cytosol] (Mus musculus)
Smurf2 [cytosol] (Mus musculus)
ub-AXIN:SMURF2 [cytosol] (Mus musculus)
Smurf2 [cytosol] (Mus musculus)
SMURF2 binds AXIN (Mus musculus)
AXIN:SMURF2 [cytosol] (Mus musculus)
Smurf2 [cytosol] (Mus musculus)
Smurf2 [cytosol] (Mus musculus)
Ubiquitinated AXIN is degraded by the proteasome (Mus musculus)
Smurf2 [cytosol] (Mus musculus)
ub-AXIN:SMURF2 [cytosol] (Mus musculus)
Smurf2 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:A2A5Z6 Smurf2
Gene Names
Smurf2
Chain
chain:1-748
Reference Genes
BioGPS Gene:66313 Smurf2
ENSEMBL:ENSMUSG00000018363.17 Smurf2
KEGG Gene (Mus musculus):66313 Smurf2
Monarch:66313 Smurf2
NCBI Gene:66313 Smurf2
UCSC:A2A5Z6 Smurf2
Reference Transcript
RefSeq:XM_006533936.3 Smurf2
RefSeq:NM_025481.2 Smurf2
Other Identifiers
10392259
10392261
107970_at
110347_i_at
110348_f_at
116070_at
1429045_at
1429046_at
1454894_at
166962_at
17271005
4322344
4363127
4444798
4492002
4575070
4616331
4628873
4770347
4795477
4799539
4853097
4928313
4957504
5082075
5138708
5169428
5212784
5213937
5274897
5280682
5319044
5333458
5399624
5423116
5524673
66313
A_52_P472660
A_52_P576886
A_52_P69740
A_55_P1976057
A_55_P2124619
GE40327
GO:0000151
GO:0003824
GO:0004842
GO:0005160
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0006511
GO:0016020
GO:0016567
GO:0016607
GO:0016740
GO:0022414
GO:0023052
GO:0030163
GO:0030512
GO:0030514
GO:0036211
GO:0042802
GO:0043161
GO:0043226
GO:0045121
GO:0046332
GO:0048856
GO:0048870
GO:0061630
GO:0140096
GO:1901165
ILMN_2426249
ILMN_2524801
ILMN_3163529
mMC003161
Participates
as a component of
SMAD7:SMURF2:Ub-TGFBR1 [plasma membrane] (Mus musculus)
ub-AXIN:SMURF2 [cytosol] (Mus musculus)
AXIN:SMURF2 [cytosol] (Mus musculus)
SMAD7:SMURF2 [cytosol] (Mus musculus)
SMAD2:SMURF2 [cytosol] (Mus musculus)
as a member of
Smurf1/2 [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
SMURF [cytosol] (Mus musculus)
as an output of
Ubiquitinated AXIN is degraded by the proteasome (Mus musculus)
SMURF2 ubiquitinates SMAD2 (Mus musculus)
as an input of
SMURF2 binds AXIN (Mus musculus)
SMURF2 binds SMAD2 (Mus musculus)
Other forms of this molecule
Smurf2 [nucleoplasm]
Inferred From
SMURF2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_006533999.1
,
NP_079757.2
Ensembl
ENSMUSP00000090177
,
ENSMUST00000092517
,
ENSMUST00000103067
,
ENSMUSG00000018363
,
ENSMUSP00000099356
PRO
A2A5Z6
MGI
1913563
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O14641 DVL2
5
pp-DVL2 [cytosol]
(R-HSA-3772398)
p-DVL2 [cytosol]
(R-HSA-201706)
p-DVL2 [clathrin-coated endocytic vesicle]
(R-HSA-5138444)
DVL2 [cytosol]
(R-HSA-201694)
ub-DVL2 [cytosol]
(R-HSA-4652689)
0.612
8
UniProt:Q9Z101 Pard6a
5
Pard6a [plasma membrane]
(R-MMU-418187)
Pard6a [cytosol]
(R-MMU-420001)
p-S345-Pard6a [cell junction]
(R-MMU-2161131)
Pard6a [cell junction]
(R-MMU-2161135)
phospho-Pard6a [plasma membrane]
(R-MMU-2134533)
0.499
2
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