Sumoylation of Cbx5 with Sumo1

Stable Identifier
R-MMU-4616026
Type
Reaction [transition]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Sumoylation of Cbx5 with Sumo1
Cbx5 (Hp1 alpha) is sumoylated at lysine-84 and other lysine residues (Maison et al. 2011, Maison et al. 2012). Sumoylated Cbx5 associates with long non-coding transcripts in pericentric heterochromatin. Sumoylation is required for initial targeting of Cbx5 to pericentric domains.
Literature References
PubMed ID Title Journal Year
22388734 The SUMO protease SENP7 is a critical component to ensure HP1 enrichment at pericentric heterochromatin

Dubarry, M, Maison, C, Almouzni, G, Romeo, K, Bailly, D, Quivy, JP

Nat. Struct. Mol. Biol. 2012
21317888 SUMOylation promotes de novo targeting of HP1? to pericentric heterochromatin

Probst, AV, Loew, D, Maison, C, Almouzni, G, Lombard, B, Dingli, F, Roche, D, Bailly, D, Quivy, JP, Vassias, I, Montes de Oca, R

Nat. Genet. 2011
Participants
Input
Output
Catalyst Activity

SUMO transferase activity of Sumo1:C93-Ube2i [nucleoplasm]

Physical Entity
Sumo1:C93-Ube2i [nucleoplasm] (Mus musculus)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
SUMOylation of CBX5 with SUMO1 (Homo sapiens)
Authored
May, B  (2013-09-21)
Reviewed
Matunis, MJ  (2017-01-22)
Yang, WC  (2017-01-22)
Lu, J  (2017-01-22)
Created
May, B  (2013-09-27)
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