Sumoylation of Cbx5 with Sumo1

Stable Identifier
R-MMU-4616026
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Sumoylation of Cbx5 with Sumo1

Cbx5 (Hp1 alpha) is sumoylated at lysine-84 and other lysine residues (Maison et al. 2011, Maison et al. 2012). Sumoylated Cbx5 associates with long non-coding transcripts in pericentric heterochromatin. Sumoylation is required for initial targeting of Cbx5 to pericentric domains.

Literature References
PubMed ID Title Journal Year
21317888 SUMOylation promotes de novo targeting of HP1? to pericentric heterochromatin

Maison, C, Bailly, D, Roche, D, Montes de Oca, R, Probst, AV, Vassias, I, Dingli, F, Lombard, B, Loew, D, Quivy, JP, Almouzni, G

Nat. Genet. 2011
22388734 The SUMO protease SENP7 is a critical component to ensure HP1 enrichment at pericentric heterochromatin

Maison, C, Romeo, K, Bailly, D, Dubarry, M, Quivy, JP, Almouzni, G

Nat. Struct. Mol. Biol. 2012
Participants
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of Sumo1:C93-Ube2i [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created