Reactome | Mdc1 [nucleoplasm]

Mdc1 [nucleoplasm]

Stable Identifier

R-MMU-4570473

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

polySUMO2,3-K1840-MDC1, Q5PSV9

Locations in the PathwayBrowser

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Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - SUMOylation (Mus musculus)
    - SUMO E3 ligases SUMOylate target proteins (Mus musculus)
      - SUMOylation of DNA damage response and repair proteins (Mus musculus)
        
        SUMOylation of MDC1 with SUMO2,3 (Mus musculus)
        
        Mdc1 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q5PSV9

Gene Names

Mdc1

Reference Genes

BioGPS Gene:240087 Mdc1

ENSEMBL:ENSMUSG00000061607

KEGG Gene (Mus musculus):240087 Mdc1

Monarch:240087 Mdc1

NCBI Gene:240087 Mdc1

Reference Transcript

RefSeq:NM_001010833.2 Mdc1

Participates

as an output of

SUMOylation of MDC1 with SUMO2,3 (Mus musculus)

Other forms of this molecule

Mdc1 [nucleoplasm]

phospho-Mdc1 [nucleoplasm]

Inferred From

polySUMO2,3-K1840-MDC1 [nucleoplasm] (Homo sapiens)

Modified Residues

Name

sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 1840 (in Homo sapiens)

Coordinate

1840

Modification

polySUMO2,3 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_001010833.2

PRO

Q5PSV9

MGI

3525201

PDB

3VA1, 3VA4

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