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phospho-MAP kinase p38 alpha [cytosol]
Stable Identifier
R-MMU-448842
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Developmental Biology (Mus musculus)
Axon guidance (Mus musculus)
Netrin-1 signaling (Mus musculus)
DSCAM interactions (Mus musculus)
Activation of p38MAPK by DSCAM (Mus musculus)
Phospho-MAP kinase p38 (Mg2+ cofactor) [cytosol] (Mus musculus)
phospho-MAPK p38 alpha/beta [cytosol] (Mus musculus)
phospho-MAP kinase p38 alpha [cytosol] (Mus musculus)
Myogenesis (Mus musculus)
Nuclear translocation of p38 MAPK (Mus musculus)
pp38 alpha/beta/gamma:ABL1:JLP:CDO complex [plasma membrane] (Mus musculus)
Phospho-p38 MAPK alpha/beta/gamma [cytosol] (Mus musculus)
phospho-MAP kinase p38 alpha [cytosol] (Mus musculus)
Hemostasis (Mus musculus)
Platelet activation, signaling and aggregation (Mus musculus)
Signal amplification (Mus musculus)
ADP signalling through P2Y purinoceptor 1 (Mus musculus)
P2Y purinoceptor 1 activates MAP kinase p38 alpha (Mus musculus)
phospho-MAP kinase p38 alpha [cytosol] (Mus musculus)
Phosphorylation of cPLA2 by MAPK p38 alpha (Mus musculus)
phospho-MAP kinase p38 alpha [cytosol] (Mus musculus)
Platelet homeostasis (Mus musculus)
Platelet sensitization by LDL (Mus musculus)
Fgr may phosphorylate p38 MAPK (Mus musculus)
phospho-MAP kinase p38 alpha [cytosol] (Mus musculus)
Phosphorylation of cPLA2 by MAPK p38 alpha (Mus musculus)
phospho-MAP kinase p38 alpha [cytosol] (Mus musculus)
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-17 signaling (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Mus musculus)
p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Mus musculus)
phospho-MAPK p38 alpha/beta [cytosol] (Mus musculus)
phospho-MAP kinase p38 alpha [cytosol] (Mus musculus)
Innate Immune System (Mus musculus)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Mus musculus)
NOD1/2 Signaling Pathway (Mus musculus)
Activation of p38 MAPK (Mus musculus)
Phospho-p38 MAPK [cytosol] (Mus musculus)
phospho-MAP kinase p38 alpha [cytosol] (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Mus musculus)
p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Mus musculus)
phospho-MAPK p38 alpha/beta [cytosol] (Mus musculus)
phospho-MAP kinase p38 alpha [cytosol] (Mus musculus)
Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Mus musculus)
p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Mus musculus)
phospho-MAPK p38 alpha/beta [cytosol] (Mus musculus)
phospho-MAP kinase p38 alpha [cytosol] (Mus musculus)
Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Mus musculus)
p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Mus musculus)
phospho-MAPK p38 alpha/beta [cytosol] (Mus musculus)
phospho-MAP kinase p38 alpha [cytosol] (Mus musculus)
Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Mus musculus)
p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Mus musculus)
phospho-MAPK p38 alpha/beta [cytosol] (Mus musculus)
phospho-MAP kinase p38 alpha [cytosol] (Mus musculus)
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88-independent TLR4 cascade (Mus musculus)
TRIF(TICAM1)-mediated TLR4 signaling (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Mus musculus)
p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Mus musculus)
phospho-MAPK p38 alpha/beta [cytosol] (Mus musculus)
phospho-MAP kinase p38 alpha [cytosol] (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Mus musculus)
p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Mus musculus)
phospho-MAPK p38 alpha/beta [cytosol] (Mus musculus)
phospho-MAP kinase p38 alpha [cytosol] (Mus musculus)
Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Mus musculus)
p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Mus musculus)
phospho-MAPK p38 alpha/beta [cytosol] (Mus musculus)
phospho-MAP kinase p38 alpha [cytosol] (Mus musculus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Mus musculus)
p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Mus musculus)
phospho-MAPK p38 alpha/beta [cytosol] (Mus musculus)
phospho-MAP kinase p38 alpha [cytosol] (Mus musculus)
Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Mus musculus)
p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Mus musculus)
phospho-MAPK p38 alpha/beta [cytosol] (Mus musculus)
phospho-MAP kinase p38 alpha [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by NTRKs (Mus musculus)
Signaling by NTRK1 (TRKA) (Mus musculus)
Signalling to ERKs (Mus musculus)
Signalling to RAS (Mus musculus)
p38MAPK events (Mus musculus)
p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Mus musculus)
Phospho-MAP kinase p38 (Mg2+ cofactor) [cytosol] (Mus musculus)
phospho-MAPK p38 alpha/beta [cytosol] (Mus musculus)
phospho-MAP kinase p38 alpha [cytosol] (Mus musculus)
Signaling by VEGF (Mus musculus)
VEGFA-VEGFR2 Pathway (Mus musculus)
p38 MAPK activation by VEGFR (Mus musculus)
Phospho-MAP kinase p38 (Mg2+ cofactor) [cytosol] (Mus musculus)
phospho-MAPK p38 alpha/beta [cytosol] (Mus musculus)
phospho-MAP kinase p38 alpha [cytosol] (Mus musculus)
p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Mus musculus)
Phospho-MAP kinase p38 (Mg2+ cofactor) [cytosol] (Mus musculus)
phospho-MAPK p38 alpha/beta [cytosol] (Mus musculus)
phospho-MAP kinase p38 alpha [cytosol] (Mus musculus)
Signaling by Rho GTPases (Mus musculus)
RHO GTPase Effectors (Mus musculus)
RHO GTPases Activate NADPH Oxidases (Mus musculus)
MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Mus musculus)
phospho-MAPK p38 alpha/beta [cytosol] (Mus musculus)
phospho-MAP kinase p38 alpha [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P47811 Mapk14
Gene Names
Mapk14, Crk1, Csbp1, Csbp2
Chain
initiator methionine:1, chain:2-360
Reference Genes
BioGPS Gene:26416 Mapk14
ENSEMBL:ENSMUSG00000053436 Mapk14
KEGG Gene (Mus musculus):26416 Mapk14
Monarch:26416 Mapk14
NCBI Gene:26416 Mapk14
UCSC:P47811 Mapk14
Reference Transcript
RefSeq:NM_001168513.1 Mapk14
RefSeq:NM_011951.3 Mapk14
RefSeq:NM_001168514.1 Mapk14
RefSeq:NM_001168508.1 Mapk14
Other Identifiers
04150+2.7.11.24
10443391
1416703_at
1416704_at
1426104_at
1451927_a_at
17335364
1LEW
1LEZ
1YW2
1YWR
232449
232450
232452
232455
26416
2EWA
2GHL
2GHM
2GTM
2GTN
2OZA
2PUU
3P4K
3P5K
3P78
3P79
3P7A
3P7B
3P7C
3PY3
3TG1
4349741
4360135
4367227
4392113
4419112
4477435
4497133
4607276
4634824
4700291
4800721
4KA3
4LOO
4LOP
4LOQ
4TYH
5026222
5057666
5134852
5175049
5296355
5365849
5376071
5555444
5587922
5LAR
5NZZ
5O90
5UOJ
99978_s_at
A0A3B2WAZ7
A0A3B2WB60
A_51_P325343
A_55_P2046338
A_55_P2179348
AAA20888
AAF06348
AAF34818
AAH12235
AAH85303
AC170998
AF128892
AF195850
AK089059
AK133684
AK151348
AK153025
B2KF34
B2KF35
BAA19741
BAC40726
BAE21782
BAE30324
BAE31659
BC012235
BC085303
CAA46200
CCDS28583
CCDS50048
CCDS50049
CH466606
CT009661
D83073
EDL22585
ENSMUSG00000053436
ENSMUSP00000004990
ENSMUSP00000061958
ENSMUSP00000110400
ENSMUSP00000110402
ENSMUSP00000110406
ENSMUST00000004990
ENSMUST00000004990.13
ENSMUST00000062694
ENSMUST00000062694.15
ENSMUST00000114752
ENSMUST00000114752.2
ENSMUST00000114754
ENSMUST00000114754.7
ENSMUST00000114758
ENSMUST00000114758.8
EntrezGene:26416
EntrezGene:Mapk14
GE37793
GO:0000003
GO:0000077
GO:0000165
GO:0000166
GO:0000902
GO:0000922
GO:0001502
GO:0001525
GO:0001890
GO:0002062
GO:0002376
GO:0002741
GO:0003674
GO:0004672
GO:0004674
GO:0004707
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005829
GO:0005856
GO:0005975
GO:0006006
GO:0006355
GO:0006357
GO:0006464
GO:0006468
GO:0006629
GO:0006810
GO:0006913
GO:0006915
GO:0006950
GO:0006974
GO:0007049
GO:0007155
GO:0007165
GO:0007178
GO:0007267
GO:0007519
GO:0007568
GO:0008022
GO:0008134
GO:0008150
GO:0008219
GO:0008283
GO:0009058
GO:0010468
GO:0010628
GO:0010759
GO:0010831
GO:0015031
GO:0016301
GO:0016310
GO:0016607
GO:0016740
GO:0018105
GO:0019395
GO:0019899
GO:0019903
GO:0030154
GO:0030278
GO:0030316
GO:0031281
GO:0031663
GO:0032495
GO:0032496
GO:0034641
GO:0035556
GO:0035924
GO:0035994
GO:0038066
GO:0040007
GO:0040011
GO:0042307
GO:0042592
GO:0042770
GO:0043167
GO:0043226
GO:0044281
GO:0045648
GO:0045663
GO:0045944
GO:0046326
GO:0046777
GO:0048010
GO:0048273
GO:0048646
GO:0048856
GO:0048870
GO:0051146
GO:0051403
GO:0051525
GO:0055085
GO:0060045
GO:0071222
GO:0071223
GO:0071356
GO:0071479
GO:0090090
GO:0090336
GO:0090400
GO:0098586
GO:0098978
GO:0099179
GO:1900015
GO:1901741
GO:1905050
GO:2000379
GO:2001184
ILMN_2491705
ILMN_2721809
IPR000719
IPR003527
IPR008352
IPR011009
IPR017441
IPR038784
Mapk14
Mapk14-201
Mapk14-202
Mapk14-203
Mapk14-204
Mapk14-205
MGI:1346865
mMC002605
NM_001168508
NM_001168513
NM_001168514
NM_011951
NP_001161980
NP_001161985
NP_001161986
NP_036081
PF00069
PR01773
Q5U421
SM00220
U10871
u10871_s_at
UPI000000190F
UPI00000EA0AF
UPI000016C8B1
UPI00005ACADB
X65067
XM_017317480
Participant Of
hasMember
phospho-MAPK p38 alpha/beta [cytosol]
Phospho-p38 MAPK alpha/beta/gamma [cytosol]
hasCandidate
Phospho-p38 MAPK [cytosol]
output
Fgr may phosphorylate p38 MAPK
P2Y purinoceptor 1 activates MAP kinase p38 alpha
Other forms of this molecule
MAPK14 [secretory granule lumen]
MAPK14 [extracellular region]
MAPK14 [ficolin-1-rich granule lumen]
MAPK14 [nucleoplasm]
p-T180,Y182-Mapk14 [nucleoplasm]
MAP kinase p38 alpha [cytosol]
Inferred From
p-T180,Y182-MAPK14 [cytosol] (Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 180
Coordinate
180
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O4'-phospho-L-tyrosine at 182
Coordinate
182
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_001161980.1
,
NP_001161985.1
,
NP_036081.1
,
NP_001161986.1
ZINC - Investigational
MK14_MOUSE
IntEnz
2.7.11.24
ZINC - Substances
MK14_MOUSE
ZINC target
P47811
PRO
P47811
ZINC - Predictions - Purchasable
MK14_MOUSE
PDB
3P7A
,
2GTN
,
5NZZ
,
6SO4
,
3P7B
,
6SO2
,
3P79
,
2EWA
,
6SP9
,
4LOP
,
3P78
,
2GHL
,
2GTM
,
6SOU
,
3P5K
,
2OZA
,
2GHM
,
6SOV
,
6SO1
,
2PUU
,
1YWR
,
3TG1
,
1LEZ
,
4LOQ
,
6SOT
,
5UOJ
,
3PY3
,
4TYH
,
1LEW
,
4LOO
,
5LAR
,
1YW2
,
6SOI
,
3P7C
,
6SPL
,
5O90
,
6SOD
,
3P4K
,
4KA3
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35236 PTPN7
1
PTPN7 [nucleoplasm]
(R-HSA-9008913)
0.589
2
IntAct:EBI-15896509 PEPMEK3B
0.558
2
UniProt:P49137-1 MAPKAPK2
0.558
2
UniProt:Q99956 DUSP9
1
DUSP9 [cytosol]
(R-HSA-5675351)
0.527
2
UniProt:P49138
5
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol]
(R-MMU-187760)
phospho-p-T222,S272-MAPKAPK2 [nucleoplasm]
(R-MMU-199936)
MAPKAPK2 [cytosol]
(R-MMU-187743)
phospho-p-T222,S272,T334-MAPKAPK2 [nucleoplasm]
(R-MMU-450268)
MAPKAPK2 [nucleoplasm]
(R-MMU-450235)
0.527
2
UniProt:Q9Z1W9 STK39
0.499
2
UniProt:P55012
1
SLC12A2 [plasma membrane]
(R-MMU-426146)
0.499
2
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