Reactome | Expression of Cebpb

Expression of Cebpb

Stable Identifier

R-MMU-442516

Type

Reaction [omitted]

Species

Mus musculus

Compartment

nucleoplasm

ReviewStatus

5/5

General

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In mouse 3T3-L1 pre-adipocytes, expression of the Cebpb and Cebpd transcription factors is activated by three factors:
1) Mitogens such as those present in fetal serum act via the Krox20 transcription factor to activate expression of Cebpb (Chen et al. 2005).
2) Glucocorticoids activate expression of Cebpd (Wu et al. 1996).
3) Hormones or drugs that increase intracellular cAMP act via pCREB and Klf4 to activate expression of Cebpb (Zhang et al. 2004, Birsoy et al. 2008).
The detailed mechanisms of activation are not yet known.

Literature References

PubMed ID	Title	Journal	Year
17011499	Transcriptional control of adipocyte formation Farmer, SR	Cell Metab	2006
14593102	Role of CREB in transcriptional regulation of CCAAT/enhancer-binding protein beta gene during adipogenesis Klemm, DJ, Zhang, JW, Vinson, C, Lane, MD	J Biol Chem	2004
1840554	Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells Umek, RM, Cao, Z, McKnight, SL	Genes Dev	1991
7557387	Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis Farmer, SR, Xie, Y, Wu, Z, Bucher, NL	Genes Dev	1995
7531665	Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins Yeh, WC, Cao, Z, Classon, M, McKnight, SL	Genes Dev	1995
8754811	Induction of peroxisome proliferator-activated receptor gamma during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPbeta, C/EBPdelta, and glucocorticoids Farmer, SR, Wu, Z, Bucher, NL	Mol Cell Biol	1996
16054051	Krox20 stimulates adipogenesis via C/EBPbeta-dependent and -independent mechanisms Spiegelman, BM, Anand, A, Chen, Z, Torrens, JI, Friedman, JM	Cell Metab	2005
9405372	Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene Kishimoto, T, Tanaka, T, Akira, S, Yoshida, N	EMBO J	1997
18396140	Transcriptional regulation of adipogenesis by KLF4 Chen, Z, Friedman, J, Birsoy, K	Cell Metab	2008

Participants

Input

Cebpb gene [nucleoplasm] (Mus musculus)

Output

Cebpb [nucleoplasm] (Mus musculus)

This event is regulated

Positively by

Regulator

Klf4 [nucleoplasm] (Mus musculus)

Regulator

Egr2 [nucleoplasm] (Mus musculus)

Orthologous Events

Expression of CEBPB in adipogenesis (Homo sapiens)

Authored

May, B (2009-05-15)

Reviewed

Sethi, JK (2011-02-10)

Created

May, B (2009-09-27)

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