Reactome | Sh2d2a [cytosol]

Sh2d2a [cytosol]

Stable Identifier

R-MMU-4420125

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

SH2D2A, Q9QXK9

Locations in the PathwayBrowser

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Signal Transduction (Mus musculus)

- Signaling by Receptor Tyrosine Kinases (Mus musculus)
  - Signaling by VEGF (Mus musculus)
    - VEGFA-VEGFR2 Pathway (Mus musculus)
      - AXL autophosphorylates on Y779 and Y821 (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:AXL [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Mus musculus)
        
        Sh2d2a [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Mus musculus)
        
        Sh2d2a [cytosol] (Mus musculus)
      - AXL binds SRC-1 (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Mus musculus)
        
        Sh2d2a [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:AXL [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Mus musculus)
        
        Sh2d2a [cytosol] (Mus musculus)
      - Phosphorylation of SRC-1 (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Mus musculus)
        
        Sh2d2a [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Mus musculus)
        
        Sh2d2a [cytosol] (Mus musculus)
      - SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Mus musculus)
        
        Sh2d2a [cytosol] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Mus musculus)
        
        Sh2d2a [cytosol] (Mus musculus)
      - VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K/VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3K [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Mus musculus)
        
        Sh2d2a [cytosol] (Mus musculus)
      - p-6Y-VEGFR2 binds SH2D2A (Mus musculus)
        
        Sh2d2a [cytosol] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Mus musculus)
        
        Sh2d2a [cytosol] (Mus musculus)
      - p-AXL binds PI3K (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Mus musculus)
        
        Sh2d2a [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Mus musculus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Mus musculus)
        
        Sh2d2a [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9QXK9

Gene Names

Sh2d2a

Reference Genes

BioGPS Gene:27371 Sh2d2a

ENSEMBL:ENSMUSG00000028071

ENSEMBL:ENSMUSG00000028071.13 Sh2d2a

KEGG Gene (Mus musculus):27371 Sh2d2a

Monarch:27371 Sh2d2a

NCBI Gene:27371 Sh2d2a

UCSC:Q9QXK9 Sh2d2a

Reference Transcript

RefSeq:NM_021309.3 Sh2d2a

Other Identifiers

100292_at

10493076

1449105_at

17398853

27371

4395032

4489510

4512737

4750322

4770386

4879365

4904613

4939328

4974956

5029753

5071157

5135291

5236712

5333479

5350053

5353393

5443404

5521100

5545278

A_51_P226882

A_66_P118141

GE38117

GO:0002376

GO:0005515

GO:0005737

GO:0005886

GO:0016020

GO:0017124

GO:0042098

ILMN_1228404

ILMN_2468455

mMC008136

Participates

as an input of

p-6Y-VEGFR2 binds SH2D2A (Mus musculus)

as a component of

VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Mus musculus)

Inferred From

SH2D2A [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_067284.1

Ensembl

ENSMUSG00000028071, ENSMUST00000029709, ENSMUSP00000103207, ENSMUST00000107581, ENSMUSP00000029709

PRO

Q9QXK9

MGI

1351596

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06240 Lck	5	phospho-p-Y394-LCK [plasma membrane] (R-MMU-8857940) Lck [cytosol] (R-MMU-539041) phospho-p-Y505-LCK [plasma membrane] (R-MMU-202159) phospho-p-Y394-LCK [cytosol] (R-MMU-202308) LCK [cytosol] (R-MMU-167609)	0.508	3