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SIRT1 [nucleoplasm]
Stable Identifier
R-MMU-427531
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
Q923E4
Locations in the PathwayBrowser
Expand all
Cellular responses to external stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular response to heat stress (Mus musculus)
Regulation of HSF1-mediated heat shock response (Mus musculus)
DBC1 binds SIRT1 (Mus musculus)
SIRT1 [nucleoplasm] (Mus musculus)
p-T454-DBC1:SIRT1 [nucleoplasm] (Mus musculus)
SIRT1 [nucleoplasm] (Mus musculus)
SIRT1 binds to HSF1 (Mus musculus)
SIRT1 [nucleoplasm] (Mus musculus)
SIRT1:HSP70:DNAJB1:Ac-K80-HSF1:target gene [nucleoplasm] (Mus musculus)
SIRT1 [nucleoplasm] (Mus musculus)
SIRT1 deacetylates HSF1 (Mus musculus)
SIRT1 [nucleoplasm] (Mus musculus)
SIRT1:HSP70:DNAJB1:Ac-K80-HSF1:target gene [nucleoplasm] (Mus musculus)
SIRT1 [nucleoplasm] (Mus musculus)
Gene expression (Transcription) (Mus musculus)
Epigenetic regulation of gene expression (Mus musculus)
Negative epigenetic regulation of rRNA expression (Mus musculus)
SIRT1 negatively regulates rRNA expression (Mus musculus)
Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Mus musculus)
SIRT1 [nucleoplasm] (Mus musculus)
eNoSC [nucleoplasm] (Mus musculus)
SIRT1 [nucleoplasm] (Mus musculus)
eNoSC deacetylates histone H3 (Mus musculus)
SIRT1 [nucleoplasm] (Mus musculus)
eNoSC [nucleoplasm] (Mus musculus)
SIRT1 [nucleoplasm] (Mus musculus)
eNoSC dimethylates histone H3 at lysine-9 (Mus musculus)
eNoSC [nucleoplasm] (Mus musculus)
SIRT1 [nucleoplasm] (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
FOXO-mediated transcription (Mus musculus)
Regulation of FOXO transcriptional activity by acetylation (Mus musculus)
SIRT1,SIRT3 deacetylate FOXO3 (Mus musculus)
SIRT1,SIRT3 [nucleoplasm] (Mus musculus)
SIRT1 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:Q923E4 Sirt1
Gene Names
Sirt1, Sir2l1
Chain
initiator methionine:1, chain:2-737, chain:2-525
Reference Genes
BioGPS Gene:93759 Sirt1
ENSEMBL:ENSMUSG00000020063 Sirt1
KEGG Gene (Mus musculus):93759 Sirt1
Monarch:93759 Sirt1
NCBI Gene:93759 Sirt1
UCSC:Q923E4 Sirt1
Reference Transcript
RefSeq:NM_019812.3 Sirt1
Other Identifiers
10369738
111531_at
115059_at
1418640_at
17241582
214046
4347990
4359481
4381779
4384877
4554421
4562215
4645704
4649340
4684892
4804148
5052557
5184515
5234347
5352978
5404804
5502505
93759
A_51_P141152
A_52_P358612
A_55_P2030428
AAF24983
AAH06584
AAR23928
AF214646
AY377984
BC006584
CCDS23898
ENSMUSG00000020063
ENSMUSP00000020257
ENSMUSP00000112595
ENSMUSP00000137565
ENSMUST00000020257
ENSMUST00000020257.12
ENSMUST00000120239
ENSMUST00000120239.7
ENSMUST00000177694
ENSMUST00000177694.7
EntrezGene:93759
EntrezGene:Sirt1
F6YAQ3
GE37604
GO:0000003
GO:0000012
GO:0000122
GO:0000183
GO:0000228
GO:0000278
GO:0000720
GO:0000731
GO:0000785
GO:0000790
GO:0000980
GO:0001228
GO:0001525
GO:0001542
GO:0001678
GO:0001934
GO:0001938
GO:0002039
GO:0002376
GO:0002821
GO:0003013
GO:0003674
GO:0003677
GO:0003700
GO:0003714
GO:0004407
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005635
GO:0005637
GO:0005654
GO:0005677
GO:0005694
GO:0005719
GO:0005720
GO:0005730
GO:0005737
GO:0005739
GO:0005829
GO:0005975
GO:0006259
GO:0006325
GO:0006343
GO:0006344
GO:0006464
GO:0006476
GO:0006629
GO:0006642
GO:0006810
GO:0006914
GO:0006915
GO:0006950
GO:0006974
GO:0006979
GO:0007049
GO:0007165
GO:0007179
GO:0007267
GO:0007275
GO:0007283
GO:0007346
GO:0007517
GO:0007568
GO:0007623
GO:0008022
GO:0008134
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0008630
GO:0009056
GO:0009058
GO:0009267
GO:0010460
GO:0010629
GO:0010667
GO:0010875
GO:0010883
GO:0010906
GO:0010934
GO:0010976
GO:0014068
GO:0014858
GO:0015031
GO:0016239
GO:0016567
GO:0016575
GO:0016605
GO:0016787
GO:0016810
GO:0017136
GO:0018394
GO:0019213
GO:0019899
GO:0019904
GO:0030154
GO:0030225
GO:0030308
GO:0030424
GO:0030426
GO:0030512
GO:0031393
GO:0031648
GO:0031937
GO:0032007
GO:0032071
GO:0032088
GO:0032720
GO:0032868
GO:0032922
GO:0032991
GO:0033210
GO:0033553
GO:0033558
GO:0034391
GO:0034641
GO:0034979
GO:0034983
GO:0035098
GO:0035257
GO:0035356
GO:0035358
GO:0035774
GO:0040007
GO:0040011
GO:0042127
GO:0042326
GO:0042393
GO:0042542
GO:0042592
GO:0042595
GO:0042632
GO:0042771
GO:0042802
GO:0042981
GO:0043065
GO:0043066
GO:0043124
GO:0043161
GO:0043167
GO:0043226
GO:0043280
GO:0043392
GO:0043398
GO:0043422
GO:0043425
GO:0043433
GO:0043518
GO:0043524
GO:0043536
GO:0044281
GO:0044321
GO:0045348
GO:0045471
GO:0045599
GO:0045722
GO:0045739
GO:0045766
GO:0045892
GO:0045944
GO:0046628
GO:0046872
GO:0046969
GO:0048511
GO:0048646
GO:0048856
GO:0048870
GO:0050872
GO:0051019
GO:0051097
GO:0051152
GO:0051276
GO:0051574
GO:0051898
GO:0055089
GO:0060125
GO:0060548
GO:0060766
GO:0061051
GO:0061647
GO:0070301
GO:0070403
GO:0070857
GO:0070914
GO:0070932
GO:0071356
GO:0071441
GO:0071456
GO:0071479
GO:0071900
GO:0090312
GO:0090335
GO:0090400
GO:0097009
GO:0097755
GO:1900113
GO:1900181
GO:1901215
GO:1901984
GO:1902166
GO:1902176
GO:1902237
GO:1903427
GO:1904179
GO:1904646
GO:1990254
GO:1990619
GO:1990830
GO:2000111
GO:2000270
GO:2000480
GO:2000481
GO:2000614
GO:2000619
GO:2000655
GO:2000757
GO:2000773
GO:2000774
ILMN_2643159
IPR003000
IPR026590
IPR026591
IPR029035
MGI:2135607
mMC005543
NM_019812
NP_062786
PF02146
Q3UNI1
Q53Z05
Sirt1
Sirt1-201
Sirt1-203
Sirt1-207
UPI00000217F8
UPI0002423F20
Participant Of
input
DBC1 binds SIRT1
Formation of energy-dependent Nucleolar Silencing Complex (eNoSC)
SIRT1 binds to HSF1
hasComponent
eNoSC [nucleoplasm]
p-T454-DBC1:SIRT1 [nucleoplasm]
SIRT1:HSP70:DNAJB1:Ac-K80-HSF1:target gene [nucleoplasm]
hasMember
SIRT1,SIRT3 [nucleoplasm]
output
SIRT1 deacetylates HSF1
Other forms of this molecule
Sirt1 [nucleoplasm]
Inferred From
SIRT1 [nucleoplasm] (Homo sapiens)
Cross References
RefSeq
NP_062786.1
PRO
Q923E4
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04637 TP53
27
TP53 [cytosol]
(R-HSA-8869337)
Unfolded TP53 [cytosol]
(R-HSA-6813797)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
SUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
Me2K-370,382-TP53 [nucleoplasm]
(R-HSA-3222242)
PolyUb,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6804446)
p-T55-TP53 [nucleoplasm]
(R-HSA-6805400)
p-S15,S20,S392-TP53 [nucleoplasm]
(R-HSA-6805053)
p-S315-TP53 [nucleoplasm]
(R-HSA-6805106)
p-S15,S20,S269,T284-TP53 [nucleoplasm]
(R-HSA-6805133)
p-S15,S20,S46-TP53 [nucleoplasm]
(R-HSA-6798369)
p-S15,S33,S46-TP53 [nucleoplasm]
(R-HSA-6805268)
p-S37-TP53 [nucleoplasm]
(R-HSA-3239022)
p-S15,S392-TP53 [nucleoplasm]
(R-HSA-3222015)
Me1-K372,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805719)
Me-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222124)
MeK-370,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222226)
p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm]
(R-HSA-6804378)
Me2-K373-TP53 [nucleoplasm]
(R-HSA-6805759)
Ac-K120,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805656)
Ac-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-5628868)
Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805631)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6793679)
PolyUb-TP53 [cytosol]
(R-HSA-6793681)
p-S15,S20-TP53 [nucleoplasm]
(R-HSA-69683)
p-S15-TP53 [nucleoplasm]
(R-HSA-69507)
TP53 [nucleoplasm]
(R-HSA-69488)
0.766
4
UniProt:O08785 Clock
2
p-S-Clock [nucleoplasm]
(R-MMU-508670)
Clock [cytosol]
(R-MMU-508720)
0.746
11
UniProt:O70343 Ppargc1a
7
p-T177,S538-Ppargc1a [nucleoplasm]
(R-MMU-1605429)
Sumo1-K183-Ppargc1a [nucleoplasm]
(R-MMU-3903008)
p-T262,S265,T298-Ppargc1a [nucleoplasm]
(R-MMU-1605518)
phospho-p-T263,S266,T299-PPARGC1A [nucleoplasm]
(R-MMU-1592224)
phospho-p-T178,S539-PPARGC1A [nucleoplasm]
(R-MMU-1592204)
PPARGC1A [nucleoplasm]
(R-MMU-442481)
Ppargc1a [nucleoplasm]
(R-MMU-556791)
0.729
6
UniProt:Q922Y0 DYRK3
0.639
7
UniProt:Q61214
1
DYRK1A [nucleoplasm]
(R-MMU-1362267)
0.61
4
UniProt:P22361 Hnf1a
1
hnf1-alpha/tcf1 [nucleoplasm]
(R-MMU-187289)
0.602
5
UniProt:P06400 RB1
3
p-S795-RB1 [nucleoplasm]
(R-HSA-69226)
RB1 [nucleoplasm]
(R-HSA-68642)
p-RB1 [nucleoplasm]
(R-HSA-188389)
0.602
4
UniProt:P37238 Pparg
2
Pparg [nucleoplasm]
(R-MMU-4717453)
Sumo1-K107,K395-Pparg [nucleoplasm]
(R-MMU-4717458)
0.589
2
UniProt:Q12778 FOXO1
5
p-T24,S256,S319-FOXO1 [nucleoplasm]
(R-HSA-199306)
FOXO1 [nucleoplasm]
(R-HSA-199300)
p-T24,S256,S319-FOXO1 [cytosol]
(R-HSA-211158)
Ac-K245,K248,K265-FOXO1 [nucleoplasm]
(R-HSA-9626942)
p-S215 FOXO1 [nucleoplasm]
(R-HSA-5692651)
0.544
2
UniProt:Q9WTL8 Arntl
2
p-S-Arntl [nucleoplasm]
(R-MMU-508690)
Arntl [cytosol]
(R-MMU-508660)
0.527
5
UniProt:O35253 Smad7
2
Smad7 [nucleoplasm]
(R-MMU-2167887)
Smad7 [cytosol]
(R-MMU-2161209)
0.524
6
UniProt:Q08999 RBL2
2
RBL2 [nucleoplasm]
(R-HSA-389102)
p-T401,S672,S1035-RBL2 [nucleoplasm]
(R-HSA-1226084)
0.524
2
UniProt:Q60974 Ncor1
3
Ncor1 [nucleoplasm]
(R-MMU-442459)
Ncor1 [cytosol]
(R-MMU-1253324)
NCOR1 [nucleoplasm]
(R-MMU-442501)
0.524
3
UniProt:P28749 RBL1
2
RBL1 [nucleoplasm]
(R-HSA-389104)
p-T369,S640,S964,S975-RBL1 [nucleoplasm]
(R-HSA-1226085)
0.524
2
UniProt:Q01094 E2F1
2
p-E2F1 [nucleoplasm]
(R-HSA-187911)
E2F1 [nucleoplasm]
(R-HSA-68639)
0.524
3
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