EphBs binds Ptk2

Stable Identifier
R-MMU-3928630
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
EphBs binds Ptk2

Focal adhesion kinase 1 (PTK2, FAK, FAK1) acts downstream of EPHB receptors in hippocampal neurons and the EPHB2-FAK signaling contributes to the dendritic spine morphogenesis and synapse maturation by suppressing the activity of actin severing cofilin through phosphorylation. Activation of EPHBs by ephrin-B (EFNB) stimulates the binding of FAK to EPHB. Knock out of FAK in mature neurons induces a shift of mushroom shaped mature dendritic spines to long filopodia like structures, suggesting that synapse formation or maturation is affected in FAK-/- neurons (Shi et al. 2009, Moeller et al. 2006).

Literature References
PubMed ID Title Journal Year
19553453 Focal adhesion kinase acts downstream of EphB receptors to maintain mature dendritic spines by regulating cofilin activity

Shi, Y, Pontrello, CG, DeFea, KA, Reichardt, LF, Ethell, IM

J. Neurosci. 2009
16298995 EphB receptors regulate dendritic spine morphogenesis through the recruitment/phosphorylation of focal adhesion kinase and RhoA activation

Moeller, ML, Shi, Y, Reichardt, LF, Ethell, IM

J. Biol. Chem. 2006
Participants
Orthologous Events
Authored
Reviewed
Created