EphB2 recruits inetersectin-1

Stable Identifier
R-MMU-3928626
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
EphB2 recruits inetersectin-1

Intersectin-1, a guanine nucleotide exchange factor (GEF) for Cdc42 is one of the binding partners of EphB in synapses. Intersectin-1 is expressed specifically in the brain and acts as the functional link between Cdc42 and EphB. EphB2 coimmunoprecipitates with intersectin-1 and the interaction is mediated by the kinase domain-containing fragment of EphB2 and the amino (N)-terminal region of intersectin-1 (Irie & Yamaguchi 2002).

Literature References
PubMed ID Title Journal Year
12389031 EphB receptors regulate dendritic spine development via intersectin, Cdc42 and N-WASP

Irie, F, Yamaguchi, Y

Nat. Neurosci. 2002
Participants
Orthologous Events
Authored
Reviewed
Created