N-Wasp binds intersectin-1

Stable Identifier
R-MMU-3928605
Type
Reaction [binding]
Species
Mus musculus
Compartment
Synonyms
Activation of intersectin-1 by EPHB and N-WASP
General
SVG |   | PPTX  | SBGN
N-Wasp binds intersectin-1

Neural Wiskott-Aldrich syndrome protein (N-WASP, WASL) with its extended proline-rich region binds simultaneously to several of the five SH3 domains of intersectin-1 (ITSN1). Double-label immunofluorescence confirmed the colocalization of ITSN1, N-WASP and EPHB2 in spines. N-WASP in cooperation with EPHB2 activates the GEF activity of intersectin-1 (Irie & Yamaguchi 2002).

Literature References
PubMed ID Title Journal Year
12389031 EphB receptors regulate dendritic spine development via intersectin, Cdc42 and N-WASP

Irie, F, Yamaguchi, Y

Nat. Neurosci. 2002
Participants
Orthologous Events
Authored
Reviewed
Created