Sumoylation of Ppargc1a with Sumo1

Stable Identifier
R-MMU-3903005
Type
Reaction [transition]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Sumoylation of Ppargc1a with Sumo1
Ppargc1a (Pgc-1alpha) is sumoylated at lysine-183 with Sumo1 (Rytinki et al. 2009, Cai et al. 2012). Sumoylation reduces transcription activation by Ppargc1a.
Literature References
PubMed ID Title Journal Year
19625249 SUMOylation attenuates the function of PGC-1alpha

Palvimo, JJ, Rytinki, MM

J. Biol. Chem. 2009
23152500 SUMO-specific protease 1 regulates mitochondrial biogenesis through PGC-1?

Yeh, ET, Yu, T, Cheng, J, Xia, X, Cai, R, Gu, J, Huang, C, Xue, S, Liu, X

J. Biol. Chem. 2012
Participants
Input
Output
Catalyst Activity

SUMO transferase activity of Sumo1:C93-Ube2i [nucleoplasm]

Physical Entity
Sumo1:C93-Ube2i [nucleoplasm] (Mus musculus)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
SUMOylation of PPARGC1A with SUMO1 (Homo sapiens)
Authored
May, B  (2013-07-15)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-07-17)
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