Reactome | Cxcr4 [plasma membrane]

Cxcr4 [plasma membrane]

Stable Identifier

R-MMU-2980772

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

CXCR4, P70658

Locations in the PathwayBrowser

Expand all

Signal Transduction (Mus musculus)

- Signaling by GPCR (Mus musculus)
  - GPCR downstream signalling (Mus musculus)
    - G alpha (i) signalling events (Mus musculus)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        CXCR4,7:CXCL12 [plasma membrane] (Mus musculus)
        
        CXCR4,7 [plasma membrane] (Mus musculus)
        
        Cxcr4 [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        CXCR4,7:CXCL12 [plasma membrane] (Mus musculus)
        
        CXCR4,7 [plasma membrane] (Mus musculus)
        
        Cxcr4 [plasma membrane] (Mus musculus)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        CXCR4,7:CXCL12 [plasma membrane] (Mus musculus)
        
        CXCR4,7 [plasma membrane] (Mus musculus)
        
        Cxcr4 [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        CXCR4,7:CXCL12 [plasma membrane] (Mus musculus)
        
        CXCR4,7 [plasma membrane] (Mus musculus)
        
        Cxcr4 [plasma membrane] (Mus musculus)
      - The Ligand:GPCR:Gi complex dissociates (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        CXCR4,7:CXCL12 [plasma membrane] (Mus musculus)
        
        CXCR4,7 [plasma membrane] (Mus musculus)
        
        Cxcr4 [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        CXCR4,7:CXCL12 [plasma membrane] (Mus musculus)
        
        CXCR4,7 [plasma membrane] (Mus musculus)
        
        Cxcr4 [plasma membrane] (Mus musculus)
  - GPCR ligand binding (Mus musculus)
    - Class A/1 (Rhodopsin-like receptors) (Mus musculus)
      - Peptide ligand-binding receptors (Mus musculus)
        
        Chemokine receptors bind chemokines (Mus musculus)
        
        Receptors CXCR4 and 7 bind CXCL12 ligand (Mus musculus)
        
        CXCR4,7 [plasma membrane] (Mus musculus)
        
        Cxcr4 [plasma membrane] (Mus musculus)
        
        CXCR4,7:CXCL12 [plasma membrane] (Mus musculus)
        
        CXCR4,7 [plasma membrane] (Mus musculus)
        
        Cxcr4 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:P70658

Gene Names

Cxcr4

Reference Genes

BioGPS Gene:12767 Cxcr4

ENSEMBL:ENSMUSG00000045382

KEGG Gene (Mus musculus):12767 Cxcr4

Monarch:12767 Cxcr4

NCBI Gene:12767 Cxcr4

UCSC:P70658 Cxcr4

Reference Transcript

RefSeq:NM_009911.3 Cxcr4

Participates

as a component of

CXCR4:CXCL12 [plasma membrane] (Mus musculus)

as a member of

CXCR4,7 [plasma membrane] (Mus musculus)

Inferred From

CXCR4 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_034041.2

ZINC - Substances

CXCR4_MOUSE

ZINC target

P70658

PRO

P70658

ZINC - Predictions - Purchasable

CXCR4_MOUSE

MGI

109563

HMDB Protein

HMDBP13791