Recruitment of Gab2 to PM and FCERI by binding to Grb2

Stable Identifier
R-MMU-2730846
Type
Reaction [binding]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Recruitment of Gab2 to PM and FCERI by binding to Grb2
NTAL cooperates with LAT in mast cells to activate PI3K pathway and cytokine production through Grb2-associated binding protein 2 (GAB2) (Gonzalez-Espinosa et al. 2003). FCERI aggregation induced translocation of a significant fraction of GAB2 from the cytosol to the plasma membrane by binding GRB2. Two of the proline-rich motifs in GAB2 are binding sites for the SH3 of GRB2. GAB2 is also recruited to plasma membrane by binding to phosphatidylinositol-3,4,5-trisphosphate (PIP3) with its plecstrin homology (PH) domain. GAB2 can be recruited to FCERI indirectly through GRB2 bound SHC1. SHC1 is recruited to the FCERI beta chain through its SH2 domain and becomes tyrosyl-phosphorylated. Phosphorylated SHC provides a docking site for the GRB2 and this in turn recruits GAB2 (Yu et al. 2006). GAB2 and PI3K are required for FCERI-induced granule translocation.
Literature References
PubMed ID Title Journal Year
16456001 Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI

Gu, H, Lowell, CA, Yu, M, Neel, BG

J. Immunol. 2006
20335178 The limited contribution of Fyn and Gab2 to the high affinity IgE receptor signaling in mast cells

Siraganian, RP, Barbu, EA, Zhang, J

J. Biol. Chem. 2010
11971018 The adapter molecule Gab2 regulates Fc epsilon RI-mediated signal transduction in mast cells

Siraganian, RP, Ambudkar, I, Xie, ZH

J. Immunol. 2002
Participants
Input
Output
Orthologous Events
Recruitment of GAB2 to PM and FCERI by binding to GRB2 (Homo sapiens)
Authored
Niarakis, A  (2012-12-21)
Reviewed
Roncagalli, R  (2013-02-13)
Created
Garapati, P V  (2012-12-05)
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