Reactome | Phosphorylated Stat3 Dimer Translocates to the Nucleus

Phosphorylated Stat3 Dimer Translocates to the Nucleus

Stable Identifier

R-MMU-2730598

Type

Reaction [omitted]

Species

Mus musculus

Compartment

cytosol, nucleoplasm

ReviewStatus

5/5

General

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Phosphorylated Stat3 Dimer Translocates to the Nucleus

Stat3 dimers are imported into the nucleus by the importin alpha/beta pathway. Stat3 constitutively shuttles into and out of the nucleus. The unphosphorylated form is predominantly cytosolic. Phosphorylation of Stat3 shifts the distribution from the cytosol to the nucleus.

Literature References

PubMed ID	Title	Journal	Year
15919823	STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3 Reich, NC, McBride, KM, Liu, L	Proc. Natl. Acad. Sci. U.S.A.	2005
14701810	Real time analysis of STAT3 nucleocytoplasmic shuttling Pranada, AL, Herrmann, A, Müller-Newen, G, Metz, S, Heinrich, PC	J. Biol. Chem.	2004
21625522	Dynamics of the STAT3 transcription factor: nuclear import dependent on Ran and importin-?1 Reich, NC, Cimica, V, Iyer, JK, Chen, HC	PLoS ONE	2011
21325026	The role of the N-terminal domain in dimerization and nucleocytoplasmic shuttling of latent STAT3 Kleshchanok, D, Poli, V, Müller-Newen, G, Vogt, M, Schmitt, A, Lehmann, S, Domoszlai, T, Richtering, W	J. Cell. Sci.	2011