Reactome | Efnb2 [plasma membrane]

Efnb2 [plasma membrane]

Stable Identifier

R-MMU-2682330

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

EFNB2, P52800

Locations in the PathwayBrowser

Expand all

Developmental Biology (Mus musculus)

- Nervous system development (Mus musculus)
  - Axon guidance (Mus musculus)
    - EPH-Ephrin signaling (Mus musculus)
      - EPH receptors autophosphorylate (Mus musculus)
        
        EPH-ephrin oligomers [plasma membrane] (Mus musculus)
        
        EPHB:EFNB oligomers [plasma membrane] (Mus musculus)
        
        EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
        
        p-EPH:ephrin oligomers [plasma membrane] (Mus musculus)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
      - EPH-ephrin mediated repulsion of cells (Mus musculus)
        
        MMP2,9 cleave EPHB (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
        
        EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
        
        SFKs phosphorylate VAV2,3 (Mus musculus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Mus musculus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Mus musculus)
        
        p-EPH:ephrin oligomers [plasma membrane] (Mus musculus)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Mus musculus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Mus musculus)
        
        p-EPH:ephrin oligomers [plasma membrane] (Mus musculus)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
        
        VAV exchanges GTP for GDP on RAC1, activating it (Mus musculus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Mus musculus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Mus musculus)
        
        p-EPH:ephrin oligomers [plasma membrane] (Mus musculus)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
        
        p-EPHs bind VAV2,3 (Mus musculus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Mus musculus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Mus musculus)
        
        p-EPH:ephrin oligomers [plasma membrane] (Mus musculus)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Mus musculus)
        
        p-EPH:ephrin oligomers [plasma membrane] (Mus musculus)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
      - EPH:EFN dimers tetramerise (Mus musculus)
        
        EPH-EFN dimers [plasma membrane] (Mus musculus)
        
        EPHB:EFNB dimers [plasma membrane] (Mus musculus)
        
        EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
        
        EPHAs:EFNAs,EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
      - EPH:EFN tetramers oligomerise (Mus musculus)
        
        EPH-EFN dimers [plasma membrane] (Mus musculus)
        
        EPHB:EFNB dimers [plasma membrane] (Mus musculus)
        
        EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
        
        EPH-ephrin oligomers [plasma membrane] (Mus musculus)
        
        EPHB:EFNB oligomers [plasma membrane] (Mus musculus)
        
        EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
        
        EPHAs:EFNAs,EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
      - EPHB-mediated forward signaling (Mus musculus)
        
        CDC42 and PIP2 bind WASL, activating it (Mus musculus)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP [plasma membrane] (Mus musculus)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP [plasma membrane] (Mus musculus)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
        
        EPHB phosphorylates TIAM1 (Mus musculus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Mus musculus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Mus musculus)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Mus musculus)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Mus musculus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Mus musculus)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Mus musculus)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
        
        EPHB2 binds KALRN (Mus musculus)
        
        EFNBs:p-EPHBs:KALRN [plasma membrane] (Mus musculus)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
        
        EPHB:NMDAR binds TIAM1 (Mus musculus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Mus musculus)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Mus musculus)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Mus musculus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Mus musculus)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Mus musculus)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
        
        KALRN exchanges GTP for GDP on RAC1, activating it (Mus musculus)
        
        EFNBs:p-EPHBs:KALRN [plasma membrane] (Mus musculus)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
        
        N-WASP binds ARP2/3 and G-actin (Mus musculus)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP [plasma membrane] (Mus musculus)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP [plasma membrane] (Mus musculus)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
        
        Ras:GTP binds p120-RasGAP (Mus musculus)
        
        p-EPHBs:EFNBs:RASA1 [plasma membrane] (Mus musculus)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs:RASA1:HRAS:GTP [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs:RASA1 [plasma membrane] (Mus musculus)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
        
        Recruitment of p190RhoGEF to p-FAK (Mus musculus)
        
        EFNBs:p-EPHBs:p-Y397-PTK2 [plasma membrane] (Mus musculus)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
        
        EFNBs:p-EPHBs:p-Y397-PTK2:ARHGEF28 [plasma membrane] (Mus musculus)
        
        EFNBs:p-EPHBs:p-Y397-PTK2 [plasma membrane] (Mus musculus)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
        
        p-EPHB phosphorylates SDC2 (Mus musculus)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
        
        p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Mus musculus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Mus musculus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Mus musculus)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Mus musculus)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
        
        p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Mus musculus)
        
        p-EPHBs:EFNBs:RASA1:HRAS:GDP [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs:RASA1 [plasma membrane] (Mus musculus)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs:RASA1:HRAS:GTP [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs:RASA1 [plasma membrane] (Mus musculus)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
        
        p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Mus musculus)
        
        EFNBs:p-EPHBs:p-Y397-PTK2:ARHGEF28 [plasma membrane] (Mus musculus)
        
        EFNBs:p-EPHBs:p-Y397-PTK2 [plasma membrane] (Mus musculus)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Mus musculus)
        
        p-EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
      - EPHBs bind EFNBs (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
        
        EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
      - Ephrin signaling (Mus musculus)
        
        EFNBs bind SDCBP (Mus musculus)
        
        EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
        
        EPHBs:EFNBs:SDCBP [plasma membrane] (Mus musculus)
        
        EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
        
        EFNBs bind SFKs (Mus musculus)
        
        EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)
        
        EPHBs:EFNBs:SRC,FYN [plasma membrane] (Mus musculus)
        
        EPHBs:EFNBs [plasma membrane] (Mus musculus)
        
        EFNBs [plasma membrane] (Mus musculus)
        
        Efnb2 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:P52800 Efnb2

Gene Names

Efnb2, Elf2, Epl5, Eplg5, Htkl, Lerk5

Chain

signal peptide:1-28, chain:29-336

Reference Genes

BioGPS Gene:13642 Efnb2

ENSEMBL:ENSMUSG00000001300.17 Efnb2

KEGG Gene (Mus musculus):13642 Efnb2

Monarch:13642 Efnb2

NCBI Gene:13642 Efnb2

UCSC:P52800 Efnb2

Reference Transcript

RefSeq:NM_010111.5 Efnb2

Other Identifiers

10576911

13642

1419638_at

1419639_at

1449548_at

1449549_at

160857_at

17507321

4311340

4341736

4406005

4546018

4892878

4950691

4951171

5005087

5021367

5193704

5198532

5310683

5322522

5449696

A_52_P340073

A_55_P2138781

GE35344

GO:0001525

GO:0001945

GO:0002042

GO:0002376

GO:0005102

GO:0005515

GO:0005886

GO:0005912

GO:0007155

GO:0007399

GO:0007411

GO:0008284

GO:0009887

GO:0010839

GO:0010977

GO:0016020

GO:0016192

GO:0023052

GO:0030154

GO:0030425

GO:0031295

GO:0034330

GO:0034332

GO:0042734

GO:0043226

GO:0043616

GO:0046875

GO:0048013

GO:0048514

GO:0048845

GO:0048856

GO:0048870

GO:0050920

GO:0070161

GO:0072178

GO:0098685

GO:0098839

GO:0098978

GO:0099054

GO:0099072

GO:0099149

GO:1903849

GO:2000727

ILMN_2716212

l38847_s_at

mMC015186

Participates

as a member of

EFNBs [plasma membrane] (Mus musculus)

Other forms of this molecule

phospho-Efnb2 [plasma membrane]

Ephrin-B2 [plasma membrane]

Inferred From

EFNB2 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_034241.2

Ensembl

ENSMUST00000001319, ENSMUSG00000001300, ENSMUSP00000001319

PRO

P52800

MGI

105097

PDB

1IKO, 1KGY

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O88797	3	Dab2 [cytosol] (R-RNO-8862456) Dab2 [lysosomal membrane] (R-RNO-2980807) Dab2 [plasma membrane] (R-RNO-2980808)	0.499	2
UniProt:Q03137 Epha4	2	Epha4 [plasma membrane] (R-MMU-3928415) phospho-p-Y596,Y602-EPHA4 [plasma membrane] (R-MMU-3928352)	0.499	2
UniProt:O55033 Nck2	2	Nck2 [cytosol] (R-MMU-8985827) Nck2 [cytosol] (R-MMU-204885)	0.462	2

Cite Us!