Jak2 Autophosphorylates in Response to Leptin

Stable Identifier
R-MMU-2586548
Type
Reaction [transition]
Species
Mus musculus
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Jak2 Autophosphorylates in Response to Leptin
Upon binding leptin the leptin receptor (Lepr) changes conformation and activates Jak2 kinase. Jak2 then phosphorylates itself, which greatly enhances its kinase activity.
Literature References
PubMed ID Title Journal Year
9405487 Divergent signaling capacities of the long and short isoforms of the leptin receptor

da Silva, B, Uotani, S, Flier, JS, Bjørbaek, C

J. Biol. Chem. 1997
20304997 Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity

Carter-Su, C, Marto, JA, Cline, JM, Argetsinger, LS, Koleva, RI, Robertson, SA, Stuckey, JA, Myers MG, Jr

Mol Endocrinol 2010
Participants
Input
Output
Catalyst Activity

protein tyrosine kinase activity of Lep:Lepr:Jak2 [plasma membrane]

Physical Entity
Lep:Lepr:Jak2 [plasma membrane] (Mus musculus)
Activity
protein tyrosine kinase activity (GO:0004713)
This event is regulated
Negatively by
Regulator
Lep:p-Lepr:p-Jak2:Socs3 [plasma membrane] (Mus musculus)
Orthologous Events
JAK2 Autophosphorylates in Response to Leptin (Homo sapiens)
Authored
May, B  (2012-11-15)
Reviewed
Scherer, T  (2013-08-31)
Gonzalez-Perez, RR  (2013-10-26)
Created
May, B  (2012-11-15)
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