p-12Y-Jak2 [cytosol]

Stable Identifier
R-MMU-2586515
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
Synonyms
Tyrosine-protein kinase JAK2 ecNumber2.7.10.2/ecNumber, JAK2_MOUSE, Jak2
Literature References
PubMed ID Title Journal Year
9111318 Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop

Matsuda, T, Witthuhn, BA, Kerr, IM, Kohlhuber, F, Feng, J, Ihle, JN

Mol Cell Biol 1997
15530433 Determination of the transphosphorylation sites of Jak2 kinase

Witthuhn, BA, Matsuda, T, Feng, J, Ihle, JN, Sekine, Y

Biochem Biophys Res Commun 2004
15065871 Tyrosine phosphorylation of the Janus kinase 2 activation loop is essential for a high-activity catalytic state but dispensable for a basal catalytic state

Duhé, RJ, Farrar, WL, Chatti, K

Biochemistry 2004
15143187 Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity

Steen, H, Carter-Su, C, Argetsinger, LS, Jensen, ON, Kouadio, JL, Stensballe, A

Mol Cell Biol 2004
19364823 Regulation of Jak2 function by phosphorylation of Tyr317 and Tyr637 during cytokine signaling

Marto, JA, Robertson, SA, Koleva, RI, Carter-Su, C, Feener, EP, Myers, MG, Argetsinger, LS

Mol. Cell. Biol. 2009
15121872 Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta

Carter-Su, C, Argetsinger, LS, Zhou, YJ, Kouadio, JL, O'Shea, JJ, Kurzer, JH

Mol Cell Biol 2004
17024180 Receptor specific downregulation of cytokine signaling by autophosphorylation in the FERM domain of Jak2

Matsuda, T, Funakoshi-Tago, M, Ihle, JN, Parganas, E, Pelletier, S

EMBO J. 2006
21726629 Phosphorylation of Y372 is critical for Jak2 tyrosine kinase activation

Tsuda, S, Caldwell-Busby, J, Sayeski, PP, Gnanasambandan, K, Sayyah, J, Kamarajugadda, S

Cell. Signal. 2011
17565041 SH2B1 enhances leptin signaling by both Janus kinase 2 Tyr813 phosphorylation-dependent and -independent mechanisms

Li, Z, Zhou, Y, Carter-Su, C, Rui, L, Myers, MG

Mol. Endocrinol. 2007
20304997 Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity

Carter-Su, C, Marto, JA, Cline, JM, Argetsinger, LS, Koleva, RI, Robertson, SA, Stuckey, JA, Myers MG, Jr

Mol Endocrinol 2010
External Reference Information
External Reference
Gene Names
Jak2
Chain
chain:1-1132
Other Identifiers
101457_at
10462363
1421065_at
1421066_at
16452
17358517
4320675
4368800
4458597
4547734
4601783
4602344
4615571
4716127
4720017
4753707
4935501
4957482
4975530
5067672
5092397
5102979
5173838
5193242
5244501
5268017
5286663
5349427
5434548
5461833
5465746
5504682
5543451
5553169
5555318
5587547
5616931
A_51_P483231
A_52_P309376
A_55_P1971458
A_66_P106863
GE34667
GO:0000166
GO:0000791
GO:0001774
GO:0002250
GO:0002376
GO:0003013
GO:0003824
GO:0004672
GO:0004713
GO:0004715
GO:0005102
GO:0005131
GO:0005143
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0005901
GO:0005925
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006366
GO:0006468
GO:0006886
GO:0006913
GO:0006919
GO:0006954
GO:0006955
GO:0006979
GO:0007155
GO:0007165
GO:0007167
GO:0007186
GO:0007204
GO:0007259
GO:0007260
GO:0008284
GO:0008285
GO:0008631
GO:0009755
GO:0010572
GO:0010667
GO:0010811
GO:0012501
GO:0012505
GO:0014070
GO:0014075
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0019221
GO:0019897
GO:0019901
GO:0020037
GO:0022408
GO:0023052
GO:0030099
GO:0030154
GO:0030218
GO:0030335
GO:0030526
GO:0031103
GO:0031234
GO:0031702
GO:0031959
GO:0032024
GO:0032496
GO:0032516
GO:0032729
GO:0032731
GO:0032740
GO:0032760
GO:0032819
GO:0033130
GO:0033194
GO:0033209
GO:0034050
GO:0034612
GO:0035166
GO:0035401
GO:0035556
GO:0035722
GO:0036016
GO:0036211
GO:0038043
GO:0038065
GO:0038156
GO:0038157
GO:0042022
GO:0042060
GO:0042102
GO:0042169
GO:0042307
GO:0042393
GO:0042531
GO:0042802
GO:0042976
GO:0042981
GO:0043065
GO:0043066
GO:0043226
GO:0043388
GO:0043410
GO:0043524
GO:0043548
GO:0043560
GO:0043687
GO:0045087
GO:0045121
GO:0045348
GO:0045428
GO:0045429
GO:0045597
GO:0045822
GO:0045944
GO:0046427
GO:0046677
GO:0046777
GO:0046872
GO:0048008
GO:0048856
GO:0048870
GO:0050727
GO:0050729
GO:0050804
GO:0050867
GO:0051091
GO:0051142
GO:0051428
GO:0051770
GO:0051897
GO:0060333
GO:0060391
GO:0060396
GO:0060397
GO:0060399
GO:0061180
GO:0070665
GO:0070671
GO:0071222
GO:0071549
GO:0072536
GO:0097012
GO:0097191
GO:0097296
GO:0098542
GO:0098794
GO:0098978
GO:0120162
GO:0140096
GO:1901731
GO:1902728
GO:1904037
GO:1904707
GO:1905539
GO:2000273
GO:2000318
GO:2001235
ILMN_1245579
ILMN_1254831
ILMN_2748786
ILMN_3115162
L16956_at
L16956_g_at
Msa.33484.0_s_at
c81467_rc_g_at
mMC005364
mMC021611
Participates
Other forms of this molecule
Inferred To
Modified Residues
Name
O4'-phospho-L-tyrosine at 868
Coordinate
868
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 966
Coordinate
966
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 972
Coordinate
972
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1008
Coordinate
1008
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 813
Coordinate
813
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 119
Coordinate
119
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 221
Coordinate
221
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 372
Coordinate
372
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 373
Coordinate
373
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 570
Coordinate
570
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 637
Coordinate
637
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1007
Coordinate
1007
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
ZINC - World Drugs
ZINC - FDA approved
IntEnz
ZINC - Substances
ZINC target
PRO
ZINC - Predictions - Purchasable
MGI
PDB
Interactors (8)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q91ZM2 Sh2b1  2 0.667 3
 UniProt:P46527 CDKN1B  8 0.626 7
 UniProt:Q00560  4 0.623 4
 UniProt:P14753 Epor  4 0.589 4
 UniProt:P48356 Lepr      0.524 3
 UniProt:Q5VWK5 IL23R  2 0.499 2
 UniProt:O35716 Socs1  2 0.482 2
 UniProt:P10686 Plcg1  8 0.463 3
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