Reactome | GRAP2 [cytosol]

GRAP2 [cytosol]

Stable Identifier

R-MMU-202367

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

O89100

Locations in the PathwayBrowser

Expand all

Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - Costimulation by the CD28 family (Mus musculus)
    - CD28 co-stimulation (Mus musculus)
      - Gads binds CD28 (Mus musculus)
        
        CD28:GRAP2 [plasma membrane] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
  - TCR signaling (Mus musculus)
    - Generation of second messenger molecules (Mus musculus)
      - Disassociation of PLC-gamma1 from SLP-76 (Mus musculus)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Mus musculus)
        
        GADS:p-5Y-LAT [plasma membrane] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
        
        phosphorylated PLC-gamma1 bound to SLP-76 [plasma membrane] (Mus musculus)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Mus musculus)
        
        GADS:p-5Y-LAT [plasma membrane] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
      - Phosphorylation of PLC-gamma1 (Mus musculus)
        
        PLC-gamma1 bound to LAT or SLP-76 [plasma membrane] (Mus musculus)
        
        PLCG1:p-3Y-SLP-76:Gads:LAT [plasma membrane] (Mus musculus)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Mus musculus)
        
        GADS:p-5Y-LAT [plasma membrane] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
        
        Phosphorylated PLC-gamma1 bound to LAT or SLP-76 [plasma membrane] (Mus musculus)
        
        phosphorylated PLC-gamma1 bound to SLP-76 [plasma membrane] (Mus musculus)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Mus musculus)
        
        GADS:p-5Y-LAT [plasma membrane] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
        
        ZAP-70 and ITK tyrosine kinases [plasma membrane] (Mus musculus)
        
        ITK:p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Mus musculus)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Mus musculus)
        
        GADS:p-5Y-LAT [plasma membrane] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
      - Phosphorylation of SLP-76 (Mus musculus)
        
        SLP-76 bound to Gads:LAT [plasma membrane] (Mus musculus)
        
        GADS:p-5Y-LAT [plasma membrane] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Mus musculus)
        
        GADS:p-5Y-LAT [plasma membrane] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
      - Recruitment of Gads to LAT (Mus musculus)
        
        GADS:p-5Y-LAT [plasma membrane] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
      - Recruitment of ITK to SLP-76 (Mus musculus)
        
        ITK:p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Mus musculus)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Mus musculus)
        
        GADS:p-5Y-LAT [plasma membrane] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Mus musculus)
        
        GADS:p-5Y-LAT [plasma membrane] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
      - Recruitment of PLC-gamma1 to SLP-76 (Mus musculus)
        
        PLCG1:p-3Y-SLP-76:Gads:LAT [plasma membrane] (Mus musculus)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Mus musculus)
        
        GADS:p-5Y-LAT [plasma membrane] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Mus musculus)
        
        GADS:p-5Y-LAT [plasma membrane] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
      - Recruitment of SLP-76 to Gads (Mus musculus)
        
        GADS:p-5Y-LAT [plasma membrane] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
        
        SLP-76 bound to Gads:LAT [plasma membrane] (Mus musculus)
        
        GADS:p-5Y-LAT [plasma membrane] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
- Innate Immune System (Mus musculus)
  - DAP12 interactions (Mus musculus)
    - DAP12 signaling (Mus musculus)
      - Activation of RAC1 by VAV2/3 (Mus musculus)
        
        p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
      - Phosphorylation and activation of VAV2/VAV3 by SYK (Mus musculus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
        
        p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
      - Phosphorylation of BTK by p-SYK (Mus musculus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
      - Phosphorylation of PLC-gamma by p-BTK/p-SYK (Mus musculus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
        
        p-SYK/p-BTK [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
      - Phosphorylation of SLP-76 by p-SYK (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Mus musculus)
        
        GADS:SLP76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
      - Recruitment of GADS:SLP-76 to p-5Y-LAT (Mus musculus)
        
        GADS:SLP76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Mus musculus)
        
        GADS:SLP76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
      - Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Mus musculus)
        
        GADS:SLP76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Mus musculus)
        
        GADS:SLP76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
      - Recruitment of VAV and BTK to p-SLP-76 (Mus musculus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
      - Release of p-PLCG1 (Mus musculus)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
  - Fc epsilon receptor (FCERI) signaling (Mus musculus)
    - FCERI mediated Ca+2 mobilization (Mus musculus)
      - Autophosphorylation of BTK/ITK (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
      - Hydrolysis of PIP2 by PLCG (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
      - Phosphorylation of TEC kinases by p-SYK (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
    - FCERI mediated MAPK activation (Mus musculus)
      - Activation of RAC1 by VAV (Mus musculus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
      - Autophosphorylation of PAK (Mus musculus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
      - Phosphorylation and activation of VAV (Mus musculus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
      - Phosphorylation of SLP-76 by p-SYK (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Mus musculus)
        
        GADS:SLP76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
      - Recruitment of GADS:SLP-76 to p-5Y-LAT (Mus musculus)
        
        GADS:SLP76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Mus musculus)
        
        GADS:SLP76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
      - Recruitment of PAK to the membrane by binding active RAC1 (Mus musculus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
      - Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Mus musculus)
        
        GADS:SLP76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Mus musculus)
        
        GADS:SLP76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
      - Recruitment of VAV to p-SLP-76 (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Mus musculus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Mus musculus)
        
        GRAP2 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:O89100

Reference Genes

BioGPS Gene:17444

ENSEMBL:ENSMUSG00000042351

KEGG Gene (Mus musculus):17444

Monarch:17444

NCBI Gene:17444

UCSC:O89100

Reference Transcript

Other Identifiers

102633_at

10425410

1420685_at

1460280_at

17313147

17444

1H3H

1OEB

1R1P

1R1Q

1R1S

1UTI

228163

228165

2D0N

2W10

4364713

4459336

4495518

4652221

4662234

4782509

4899922

4994215

5087101

5181111

5205719

5260784

5277011

5537125

5586648

A0A2R8VH91

A0A2R8VHI5

A_52_P120612

A_52_P150683

AAC98669

AAD08803

AAD41783

AAF60318

AAH52496

AF053405

AF055465

AF129477

AF236118

AJ011735

AK156939

BAE33906

BC052496

CAA09756

CCDS27663

CH466550

EDL04599

ENSMUSG00000042351

ENSMUSP00000046532

ENSMUSP00000155681

ENSMUST00000043149

ENSMUST00000043149.8

ENSMUST00000229980

ENSMUST00000229980.1

EntrezGene:17444

EntrezGene:Grap2

GE119100

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005768

GO:0031410

GO:0043226

Grap2

Grap2-201

Grap2-202

ILMN_1218749

ILMN_2711241

ILMN_2711242

ILMN_3113787

IPR000980

IPR001452

IPR035646

IPR036028

IPR036860

MGI:1333842

mMC007464

mMC021078

NM_001289442

NM_010815

NP_001276371

NP_034945

PF00017

PF00018

PR00401

PR00452

Q3U0E8

SM00252

SM00326

UPI0000025831

Participant Of

hasMember

Adapter proteins [cytosol]

input

hasComponent

Inferred From

GRAP2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_034945.1, NP_001276371.1

PRO

O89100

PDB

1R1Q, 2D0N, 2W10, 1H3H, 1R1S, 1OEB, 1R1P, 1UTI

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13094 LCP2	2	p-Y113,128,145-LCP2 [cytosol] (R-HSA-202175) LCP2 [cytosol] (R-HSA-202306)	0.835	7
UniProt:P40818 USP8	2	p-T945-USP8 [cytosol] (R-HSA-1358714) USP8 [cytosol] (R-HSA-917720)	0.75	4
UniProt:Q9QUN3	2	phospho-p-5Y-BLNK [plasma membrane] (R-MMU-983579) BLNK [cytosol] (R-MMU-912750)	0.658	4
UniProt:Q6PB44 PTN23			0.618	3
UniProt:O35601 Fyb1	2	FYB [cytosol] (R-MMU-390925) Adap [cytosol] (R-MMU-430207)	0.611	3
UniProt:Q8WV28 BLNK	2	p-5Y-BLNK [plasma membrane] (R-HSA-983579) BLNK [cytosol] (R-HSA-912750)	0.609	2
UniProt:Q9H3S7 PTPN23	1	PTPN23 [nucleoplasm] (R-HSA-9008924)	0.602	3
UniProt:P70218 M4K1			0.558	2
UniProt:Q80U87	2	USP8 [cytosol] (R-MMU-917720) phospho-p-T945-USP8 [cytosol] (R-MMU-1358714)	0.544	4
UniProt:Q60787 Lcp2	2	phospho-p-Y113,128,145-LCP2 [cytosol] (R-MMU-202175) SLP-76 [cytosol] (R-MMU-430203)	0.499	7
UniProt:P09581	1	CSF1R [plasma membrane] (R-MMU-197667)	0.482	2