Reactome | COPA [cytosol]

COPA [cytosol]

Stable Identifier

R-MMU-199978

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

Q8CIE6

Locations in the PathwayBrowser

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Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - Asparagine N-linked glycosylation (Mus musculus)
    - Transport to the Golgi and subsequent modification (Mus musculus)
      - ER to Golgi Anterograde Transport (Mus musculus)
        
        COPI-mediated anterograde transport (Mus musculus)
        
        ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Mus musculus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        coatomer [cytosol] (Mus musculus)
        
        trimeric coatomer complex [cytosol] (Mus musculus)
        
        COPA [cytosol] (Mus musculus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        coatomer [cytosol] (Mus musculus)
        
        trimeric coatomer complex [cytosol] (Mus musculus)
        
        COPA [cytosol] (Mus musculus)
        
        ARFGAPs stimulate ARF GTPase activity (Mus musculus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        coatomer [cytosol] (Mus musculus)
        
        trimeric coatomer complex [cytosol] (Mus musculus)
        
        COPA [cytosol] (Mus musculus)
        
        Active ARF recruits coatomer (Mus musculus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        coatomer [cytosol] (Mus musculus)
        
        trimeric coatomer complex [cytosol] (Mus musculus)
        
        COPA [cytosol] (Mus musculus)
        
        coatomer [cytosol] (Mus musculus)
        
        trimeric coatomer complex [cytosol] (Mus musculus)
        
        COPA [cytosol] (Mus musculus)
        
        COPI vesicle uncoating (Mus musculus)
        
        coatomer [cytosol] (Mus musculus)
        
        trimeric coatomer complex [cytosol] (Mus musculus)
        
        COPA [cytosol] (Mus musculus)

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - ER to Golgi Anterograde Transport (Mus musculus)
    - COPI-mediated anterograde transport (Mus musculus)
      - ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Mus musculus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        coatomer [cytosol] (Mus musculus)
        
        trimeric coatomer complex [cytosol] (Mus musculus)
        
        COPA [cytosol] (Mus musculus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        coatomer [cytosol] (Mus musculus)
        
        trimeric coatomer complex [cytosol] (Mus musculus)
        
        COPA [cytosol] (Mus musculus)
      - ARFGAPs stimulate ARF GTPase activity (Mus musculus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        coatomer [cytosol] (Mus musculus)
        
        trimeric coatomer complex [cytosol] (Mus musculus)
        
        COPA [cytosol] (Mus musculus)
      - Active ARF recruits coatomer (Mus musculus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        coatomer [cytosol] (Mus musculus)
        
        trimeric coatomer complex [cytosol] (Mus musculus)
        
        COPA [cytosol] (Mus musculus)
        
        coatomer [cytosol] (Mus musculus)
        
        trimeric coatomer complex [cytosol] (Mus musculus)
        
        COPA [cytosol] (Mus musculus)
      - COPI vesicle uncoating (Mus musculus)
        
        coatomer [cytosol] (Mus musculus)
        
        trimeric coatomer complex [cytosol] (Mus musculus)
        
        COPA [cytosol] (Mus musculus)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Mus musculus)
    - Golgi-to-ER retrograde transport (Mus musculus)
      - COPI-dependent Golgi-to-ER retrograde traffic (Mus musculus)
        
        ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Mus musculus)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer [Golgi membrane] (Mus musculus)
        
        coatomer [cytosol] (Mus musculus)
        
        trimeric coatomer complex [cytosol] (Mus musculus)
        
        COPA [cytosol] (Mus musculus)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo [Golgi membrane] (Mus musculus)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer [Golgi membrane] (Mus musculus)
        
        coatomer [cytosol] (Mus musculus)
        
        trimeric coatomer complex [cytosol] (Mus musculus)
        
        COPA [cytosol] (Mus musculus)
        
        ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Mus musculus)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo [Golgi membrane] (Mus musculus)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer [Golgi membrane] (Mus musculus)
        
        coatomer [cytosol] (Mus musculus)
        
        trimeric coatomer complex [cytosol] (Mus musculus)
        
        COPA [cytosol] (Mus musculus)
        
        Active ARF recruits coatomer to the Golgi (Mus musculus)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer [Golgi membrane] (Mus musculus)
        
        coatomer [cytosol] (Mus musculus)
        
        trimeric coatomer complex [cytosol] (Mus musculus)
        
        COPA [cytosol] (Mus musculus)
        
        coatomer [cytosol] (Mus musculus)
        
        trimeric coatomer complex [cytosol] (Mus musculus)
        
        COPA [cytosol] (Mus musculus)
        
        COPI vesicle uncoating at the ER (Mus musculus)
        
        coatomer [cytosol] (Mus musculus)
        
        trimeric coatomer complex [cytosol] (Mus musculus)
        
        COPA [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8CIE6

Reference Genes

BioGPS Gene:12847

ENSEMBL:ENSMUSG00000026553

KEGG Gene (Mus musculus):12847

Monarch:12847

NCBI Gene:12847

UCSC:Q8CIE6

Reference Transcript

RefSeq:NM_009938.4

Other Identifiers

10338123

10338298

10338437

10339036

10339139

10339221

10339741

10339873

10339876

10340363

10340573

10340600

10340658

10340754

10340858

10340990

10341061

10341570

10341705

10341792

10341797

10341956

10342096

10342307

10342308

10342369

10342459

10342568

10342673

10342681

10342945

10343198

10343255

10343973

10344587

10351703

12847

1415706_at

17219448

181703

4306490

4306955

4315463

4388514

4403546

4416369

4450035

4513648

4521461

4548824

4601931

4664005

4695971

4698520

4709441

4749684

4770411

4824434

5000403

5052942

5065999

5146564

5151860

5154302

5156821

5187061

5192520

5238988

5295152

5315707

5321430

5323018

5376800

5382752

5430603

5484208

5550334

5593775

5601215

5A1U

5A1V

5A1W

5A1X

5A1Y

5NZR

5NZS

5NZT

5NZU

5NZV

96854_at

A_51_P109335

A_52_P272519

A_55_P2185712

aa259908_at

aa259908_g_at

AAH24070

AAH47429

AC158930

BC024070

BC047429

CCDS35780

Copa

Copa-206

D6RH55

ENSMUSG00000026553

ENSMUSP00000118179

ENSMUST00000135192

ENSMUST00000135192.7

EntrezGene:12847

EntrezGene:Copa

F8WHL2

GE33146

GO:0000139

GO:0003674

GO:0005179

GO:0005198

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005737

GO:0005794

GO:0006810

GO:0006886

GO:0006888

GO:0006890

GO:0006891

GO:0007165

GO:0008150

GO:0015031

GO:0016020

GO:0016192

GO:0030117

GO:0030126

GO:0030157

GO:0030663

GO:0031410

GO:0032991

GO:0043226

ILMN_1228135

ILMN_2681906

IPR001680

IPR006692

IPR010714

IPR011048

IPR015943

IPR016391

IPR017986

IPR019775

IPR020472

IPR024977

IPR036322

MGI:1334462

mMC025772

NM_009938

NP_034068

PF00400

PF04053

PF06957

PF12894

PR00320

SM00320

UPI00001C2499

XM_011238748

XP_011237050

Participant Of

hasComponent

trimeric coatomer complex [cytosol]

Other forms of this molecule

COPA [endoplasmic reticulum membrane]

COPA [Golgi membrane]

COPA [transport vesicle]

Inferred From

COPA [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_034068.3

PRO

Q8CIE6

PDB

5NZT, 5NZV, 5A1Y, 5NZR, 5A1V, 5A1X, 5NZS, 5NZU, 5A1W, 5A1U

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P51572 BCAP31	5	BCAP31(238-246) [cytosol] (R-HSA-351912) BCAP31 [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985503) BCAP31(2-164) [endoplasmic reticulum membrane] (R-HSA-351826) BCAP31(165-237) [endoplasmic reticulum membrane] (R-HSA-351909) BCAP31(2-245) [endoplasmic reticulum membrane] (R-HSA-201587)	0.564	2