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beta-NGF homodimer [extracellular region]
Stable Identifier
R-MMU-198272
Type
Complex
Species
Mus musculus
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Signal Transduction (Mus musculus)
Death Receptor Signaling (Mus musculus)
p75 NTR receptor-mediated signalling (Mus musculus)
Cell death signalling via NRAGE, NRIF and NADE (Mus musculus)
NADE modulates death signalling (Mus musculus)
14-3-3epsilon attentuates NADE-related apoptosis (Mus musculus)
NGF ligand:p75NTR:NADE:14-3-3epsilon [plasma membrane] (Mus musculus)
NGF:p75NTR:NADE [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
NGF:p75NTR:NADE [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
p75NTR binds to NADE (Mus musculus)
NGF:p75NTR:NADE [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
p75NTR:NADE promotes caspase2/3 activation (Mus musculus)
NGF:p75NTR:NADE [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
NRIF signals cell death from the nucleus (Mus musculus)
TRAF6 binds to p75NTR:NRIF (Mus musculus)
NGF ligand:p75NTR:NRIF [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:NRIF [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Mus musculus)
NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:NRIF [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
NFG and proNGF binds to p75NTR (Mus musculus)
NGF homodimer binds to p75NTR (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
p75NTR regulates axonogenesis (Mus musculus)
Axonal growth stimulation (Mus musculus)
NGF binding to p75NTR inactivates RHOA (Mus musculus)
RHOA:GDP:ARHGDIA:NGFR:NGF [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
p75NTR signals via NF-kB (Mus musculus)
NF-kB is activated and signals survival (Mus musculus)
IKKbeta is activated (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
p75NTR recruits signalling complexes (Mus musculus)
IKK-beta is recruited (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
IRAK interacts with TRAF6 (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
MYD88 dissociates (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
TRAF6 is auto-ubiquitinated (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
p62 is recruited and forms a complex with TRAF6 (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
p62 recruits an atypical PKC (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:aPKCi [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Mus musculus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
p75NTR interacts with RIP2 (Mus musculus)
NGF:p75NTR:RIP2 [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by NTRKs (Mus musculus)
Expression and Processing of Neurotrophins (Mus musculus)
NGF processing (Mus musculus)
Pro-beta-NGF and mature beta-NGF are secreted (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
Signaling by NTRK1 (TRKA) (Mus musculus)
Activation of TRKA receptors (Mus musculus)
TRKA activation by NGF (Mus musculus)
Activated TrkA receptor internalizes to endosomes (Mus musculus)
Activated TrkA receptor complex [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
The bound receptor dimerizes (Mus musculus)
beta-NGF dimer:TrkA receptor [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF dimer:TrkA receptor dimer [plasma membrane] (Mus musculus)
beta-NGF dimer:TrkA receptor [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF dimer binds to TrkA receptor (Mus musculus)
beta-NGF dimer:TrkA receptor [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
PI3K/AKT activation (Mus musculus)
Active IRS recruits PI3K to the plasma membrane and activates it (Mus musculus)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Mus musculus)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
Retrograde neurotrophin signalling (Mus musculus)
Axonal transport of NGF:Trk complexes (Mus musculus)
Activated TrkA receptor complex:Clathrin-coated vesicle:Endophilin [plasma membrane] (Mus musculus)
Activated TrkA receptor complex [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
Signalling to ERKs (Mus musculus)
Prolonged ERK activation events (Mus musculus)
ARMS-mediated activation (Mus musculus)
ARMS is phosphorylated by active TrkA receptor (Mus musculus)
Active TrkA receptor:ARMS:Crk complex [plasma membrane] (Mus musculus)
Activated TrkA receptor complex [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Mus musculus)
Activated TrkA receptor complex [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
C3G stimulates nucleotide exchange on Rap1 (Mus musculus)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Mus musculus)
Activated TrkA receptor complex [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
Crk's SH3 domain engages C3G (Mus musculus)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Mus musculus)
Activated TrkA receptor complex [plasma membrane] (Mus musculus)
beta-NGF homodimer [extracellular region] (Mus musculus)
Participants
components
x 2
beta-NGF [extracellular region]
(Mus musculus)
Participates
as an input of
NGF binding to p75NTR inactivates RHOA (Mus musculus)
NGF homodimer binds to p75NTR (Mus musculus)
beta-NGF dimer binds to TrkA receptor (Mus musculus)
as a component of
RHOA:GDP:ARHGDIA:NGFR:NGF [plasma membrane] (Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane] (Mus musculus)
beta-NGF dimer:TrkA receptor [plasma membrane] (Mus musculus)
Activated NTRK-1:Phospho-IRS1/2 [plasma membrane] (Mus musculus)
Activated NTRK-1:IRS1/2 [plasma membrane] (Mus musculus)
Activated NTRK-1 [plasma membrane] (Mus musculus)
Activated TrkA receptor complex [plasma membrane] (Mus musculus)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Mus musculus)
as an output of
Pro-beta-NGF and mature beta-NGF are secreted (Mus musculus)
Inferred From
mature beta-NGF homodimer [extracellular region]
(Homo sapiens)
beta-NGF homodimer [extracellular region]
(Homo sapiens)
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