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PTPN6 [cytosol]
Stable Identifier
R-MMU-197938
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
P29351
Locations in the PathwayBrowser
Expand all
Hemostasis (Mus musculus)
Cell surface interactions at the vascular wall (Mus musculus)
PECAM1 interactions (Mus musculus)
Interaction of PECAM-1 and SHP-1 (Mus musculus)
PECAM-1:SHP-1 complex [plasma membrane] (Mus musculus)
PTPN6 [cytosol] (Mus musculus)
PTPN6 [cytosol] (Mus musculus)
Platelet activation, signaling and aggregation (Mus musculus)
GPVI-mediated activation cascade (Mus musculus)
G6B binds PTPN6,PTPN11 (Mus musculus)
G6B:PTPN6,PTPN11 [plasma membrane] (Mus musculus)
PTPN6,PTPN11 [cytosol] (Mus musculus)
PTPN6 [cytosol] (Mus musculus)
PTPN6,PTPN11 [cytosol] (Mus musculus)
PTPN6 [cytosol] (Mus musculus)
SYK autophosphorylates (Mus musculus)
G6B:PTPN6,PTPN11 [plasma membrane] (Mus musculus)
PTPN6,PTPN11 [cytosol] (Mus musculus)
PTPN6 [cytosol] (Mus musculus)
p-Y7-CLEC1B dimer:PDPN binds SYK (Mus musculus)
G6B:PTPN6,PTPN11 [plasma membrane] (Mus musculus)
PTPN6,PTPN11 [cytosol] (Mus musculus)
PTPN6 [cytosol] (Mus musculus)
Platelet homeostasis (Mus musculus)
Platelet sensitization by LDL (Mus musculus)
Interaction of PECAM-1 and SHP-1 (Mus musculus)
PECAM-1:SHP-1 complex [plasma membrane] (Mus musculus)
PTPN6 [cytosol] (Mus musculus)
PTPN6 [cytosol] (Mus musculus)
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Costimulation by the CD28 family (Mus musculus)
PD-1 signaling (Mus musculus)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Mus musculus)
PTPN6,PTPN11 [cytosol] (Mus musculus)
PTPN6 [cytosol] (Mus musculus)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Mus musculus)
PTPN6,PTPN11 [cytosol] (Mus musculus)
PTPN6 [cytosol] (Mus musculus)
Interaction of SHP-1 or SHP-2 with phospho PD-1 (Mus musculus)
PTPN6,PTPN11 [cytosol] (Mus musculus)
PTPN6 [cytosol] (Mus musculus)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Mus musculus)
PTPN6,PTPN11 [cytosol] (Mus musculus)
PTPN6 [cytosol] (Mus musculus)
SHP-1 and SHP-2 bind pBTLA (Mus musculus)
PTPN6,PTPN11 [cytosol] (Mus musculus)
PTPN6 [cytosol] (Mus musculus)
SHP-1/SHP-2:pBTLA:HVEM [plasma membrane] (Mus musculus)
PTPN6,PTPN11 [cytosol] (Mus musculus)
PTPN6 [cytosol] (Mus musculus)
Signaling by the B Cell Receptor (BCR) (Mus musculus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Mus musculus)
SYK autophosphorylates at the activated BCR (Mus musculus)
PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Mus musculus)
PTPN6 [cytosol] (Mus musculus)
CD22 mediated BCR regulation (Mus musculus)
SHP1 binds p-CD22 (Mus musculus)
PTPN6 [cytosol] (Mus musculus)
PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Mus musculus)
PTPN6 [cytosol] (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Interferon Signaling (Mus musculus)
Interferon alpha/beta signaling (Mus musculus)
Regulation of IFNA/IFNB signaling (Mus musculus)
Dephosphorylation of JAK1 by SHP1 (Mus musculus)
PTPN6 [cytosol] (Mus musculus)
Interferon gamma signaling (Mus musculus)
Transphosphorylation of JAK1 (Mus musculus)
PTPN6 [cytosol] (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-2 family signaling (Mus musculus)
Interleukin receptor SHC signaling (Mus musculus)
The SHC1:SHIP1 complex is stabilized by GRB2 (Mus musculus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Mus musculus)
PTPN6 [cytosol] (Mus musculus)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Mus musculus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Mus musculus)
PTPN6 [cytosol] (Mus musculus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Mus musculus)
Interleukin receptor SHC signaling (Mus musculus)
The SHC1:SHIP1 complex is stabilized by GRB2 (Mus musculus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Mus musculus)
PTPN6 [cytosol] (Mus musculus)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Mus musculus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Mus musculus)
PTPN6 [cytosol] (Mus musculus)
SHP1 and SHP2 bind the common beta chain (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Mus musculus)
PTPN6,PTPN11 [cytosol] (Mus musculus)
PTPN6 [cytosol] (Mus musculus)
PTPN6,PTPN11 [cytosol] (Mus musculus)
PTPN6 [cytosol] (Mus musculus)
SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] (Mus musculus)
PTPN6,PTPN11 [cytosol] (Mus musculus)
PTPN6 [cytosol] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Mus musculus)
PTPN6,PTPN11 [cytosol] (Mus musculus)
PTPN6 [cytosol] (Mus musculus)
PTPN6,PTPN11 [cytosol] (Mus musculus)
PTPN6 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by ALK (Mus musculus)
PTPN6 dephosphorylates JAK3 (Mus musculus)
PTPN6 [cytosol] (Mus musculus)
Signaling by SCF-KIT (Mus musculus)
Regulation of KIT signaling (Mus musculus)
Interaction of SHP1 and KIT (Mus musculus)
PTPN6 [cytosol] (Mus musculus)
PTPN6:p-c-Kit complex [plasma membrane] (Mus musculus)
PTPN6 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P29351 Ptpn6
Gene Names
Ptpn6, Hcp, Hcph, Ptp1C
Chain
chain:1-595
Reference Genes
BioGPS Gene:15170 Ptpn6
ENSEMBL:ENSMUSG00000004266.16 Ptpn6
KEGG Gene (Mus musculus):15170 Ptpn6
Monarch:15170 Ptpn6
NCBI Gene:15170 Ptpn6
UCSC:P29351 Ptpn6
Reference Transcript
RefSeq:NM_001077705.2 Ptpn6
RefSeq:NM_013545.3 Ptpn6
Other Identifiers
102851_s_at
10547769
1456694_x_at
1460188_at
15170
17470796
4373182
4418904
4439616
4502028
4535409
4672473
4679633
4696525
4742764
4755766
5035444
5103560
5152480
5164263
5206978
5307600
5378915
5408721
5469619
5500226
A_52_P114722
A_52_P666779
A_55_P2505725
GE36643
GO:0000165
GO:0000278
GO:0001784
GO:0002244
GO:0002376
GO:0002924
GO:0003824
GO:0004721
GO:0004725
GO:0004726
GO:0005001
GO:0005126
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005829
GO:0005886
GO:0005911
GO:0006470
GO:0006954
GO:0007155
GO:0008284
GO:0016311
GO:0016787
GO:0016791
GO:0017124
GO:0019221
GO:0019901
GO:0023052
GO:0030154
GO:0030220
GO:0032715
GO:0032720
GO:0032991
GO:0033007
GO:0033630
GO:0035556
GO:0035855
GO:0036211
GO:0042060
GO:0042098
GO:0042105
GO:0042130
GO:0042169
GO:0042267
GO:0043226
GO:0043409
GO:0045577
GO:0046703
GO:0048856
GO:0050732
GO:0050839
GO:0050852
GO:0050853
GO:0050860
GO:0051279
GO:0051897
GO:0055065
GO:0055085
GO:0060089
GO:0070372
GO:0070527
GO:0071310
GO:0097440
GO:0098542
GO:0106015
GO:0140031
GO:0140096
GO:1905867
GO:2000045
ILMN_1220996
ILMN_3113420
ac002397_genePTPN6_s_at
mMC011296
Participates
as a component of
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Mus musculus)
PTPN6:p-c-Kit complex [plasma membrane] (Mus musculus)
PECAM-1:SHP-1 complex [plasma membrane] (Mus musculus)
PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Mus musculus)
as an input of
SHP1 binds p-CD22 (Mus musculus)
Interaction of SHP1 and KIT (Mus musculus)
Interaction of PECAM-1 and SHP-1 (Mus musculus)
as a member of
PTPN6,PTPN11 [cytosol] (Mus musculus)
This entity regulates
Negatively
Transphosphorylation of JAK1
(Mus musculus)
Other forms of this molecule
PTPN6 [tertiary granule lumen]
PTPN6 [extracellular region]
PTPN6 [specific granule lumen]
Ptpn6 [cytosol]
Inferred From
PTPN6 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001071173.1
,
NP_038573.2
Ensembl
ENSMUST00000112484
,
ENSMUST00000174265
,
ENSMUST00000171549
,
ENSMUSP00000133991
,
ENSMUST00000004377
,
ENSMUSG00000004266
,
ENSMUSP00000108103
,
ENSMUSP00000004377
,
ENSMUSP00000129124
PRO
P29351
MGI
96055
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q78DX7 ROS1
0.593
3
UniProt:P28776
1
IDO1 [cytosol]
(R-MMU-198574)
0.537
5
UniProt:P35329
3
NAc-CD22 [plasma membrane]
(R-MMU-5690736)
CD22 [plasma membrane]
(R-MMU-197703)
phospho-p-Y762,807,822-CD22 [plasma membrane]
(R-MMU-5690726)
0.527
5
UniProt:B7UM99 TIR
0.524
2
UniProt:P51432
1
Plcb3 [cytosol]
(R-MMU-61747)
0.499
4
UniProt:Q91YS8
1
CAMK1 [cytosol]
(R-MMU-9619207)
0.499
3
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