HNF1a regulates Foxa3

Stable Identifier
R-MMU-186617
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
HNF1a regulates Foxa3
HNF1a was shown to bind a 3'-region of the Foxa3 (Hnf3g) gene by chromatin immunoprecipitation (Boj et al. 2001). The deletion in mice of an enhancer region that binds HNF1a located in the 3' region of the Foxa3 gene was shown to affect Foxa3 gene expression in liver, pancreas and gut (Hiemisch et al. 1997). Genetic evidence exists that HNF1a regulates Foxa3 in Hnf1alpha -/- mice (Boj et al. 2001).
Literature References
PubMed ID Title Journal Year
11717395 A transcription factor regulatory circuit in differentiated pancreatic cells

Parrizas, M, Maestro, MA, Ferrer, J, Boj, SF

Proc Natl Acad Sci U S A 2001
9233809 Transcriptional regulation in endoderm development: characterization of an enhancer controlling Hnf3g expression by transgenesis and targeted mutagenesis

Schutz, G, Kaestner, KH, Hiemisch, H

EMBO J 1997
Participants
Output
This event is regulated
Positively by
Regulator
hnf1-alpha/tcf1 [nucleoplasm] (Mus musculus)
Orthologous Events
HNF1A-dependent synthesis of FOXA3 (Homo sapiens)
Authored
Tello-Ruiz, MK  (2008-05-24)
Ferrer, J  (2008-05-24)
Reviewed
Jensen, J  (2008-05-13)
Created
Tello-Ruiz, MK  (2006-08-14)
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