pro-NGF dimerizes

Stable Identifier
R-MMU-181822
Type
Reaction [binding]
Species
Mus musculus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
pro-NGF dimerizes
The pro-neurotrophin (pro-NGF: 27 kDa) spontaneously forms stable, non-covalent dimers directly in the ER. The homodimer is associated by noncovalent forces, with an equilibrium dissociation constant of 10 pM. The neurotrophin pro- domain is important for proper folding and intracellular sorting. Heterodimers of different neurotrophin monomers can also be generated at the ER.
Literature References
PubMed ID Title Journal Year
925010 Dissociation equilibrium constant of beta nerve growth factor

Shooter, EM, Bothwell, MA

J Biol Chem 1977
Participants
Orthologous Events
Created
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