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Terf2 [nucleoplasm]
Stable Identifier
R-MMU-174895
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
TERF2, O35144
Locations in the PathwayBrowser
Expand all
Cell Cycle (Mus musculus)
Chromosome Maintenance (Mus musculus)
Telomere Maintenance (Mus musculus)
Extension of Telomeres (Mus musculus)
Telomere C-strand (Lagging Strand) Synthesis (Mus musculus)
Disassociation of Processive Complex and Completed Telomere End (Mus musculus)
Extended And Processed Telomere End [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:ligated C-strand Okazaki fragments [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Polymerase switching on the C-strand of the telomere (Mus musculus)
Formation of Processive Complex on the C-strand of the telomere (Mus musculus)
Processive complex loaded on telomere [nucleoplasm] (Mus musculus)
RNA primer-DNA primer:G-strand extended telomere:PCNA [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
RNA primer-DNA primer:G-strand extended telomere:PCNA [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Mus musculus)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer [nucleoplasm] (Mus musculus)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
RFC binding displaces Pol Alpha on the C-strand of the telomere (Mus musculus)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
RNA primer:DNA primer:G-strand extended telomere:POLA:primase [nucleoplasm] (Mus musculus)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
RFC dissociates after sliding clamp formation on the C-strand of the telomere (Mus musculus)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer [nucleoplasm] (Mus musculus)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
RNA primer-DNA primer:G-strand extended telomere:PCNA [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Processive synthesis on the C-strand of the telomere (Mus musculus)
Formation of C-strand Okazaki fragments (Mus musculus)
Processive complex loaded on telomere [nucleoplasm] (Mus musculus)
RNA primer-DNA primer:G-strand extended telomere:PCNA [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment complex [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Formation of the Flap Intermediate on the C-strand (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment complex [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Joining of adjacent Okazaki fragments of the C-strand (Mus musculus)
Processive complex loaded on telomere:ligated C-strand Okazaki fragments [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:nicked DNA from adjacent Okazaki fragments [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Removal of the Flap Intermediate from the C-strand (Mus musculus)
RPA binds to the Flap on the C-strand (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Recruitment of DNA2 endonuclease to the C strand (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer:DNA2 [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer:DNA2 [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:Okazaki fragments:Remaining Flap [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Removal of remaining Flap from the C-strand (Mus musculus)
Processive complex loaded on telomere:Okazaki fragments:Remaining Flap [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:nicked DNA from adjacent Okazaki fragments [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Telomere C-strand synthesis initiation (Mus musculus)
DNA polymerase:primase binds G-strand of the telomere (Mus musculus)
POLA:primase:G-strand extended telomere end [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Telomeric G-strand chromosome end with two additional single strand repeats [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Mus musculus)
RNA primer:DNA primer:G-strand extended telomere:POLA:primase [nucleoplasm] (Mus musculus)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Mus musculus)
POLA:primase:G-strand extended telomere end [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Telomere Extension By Telomerase (Mus musculus)
Alignment Of The RNA Template On The Telomeric Chromosome End (Mus musculus)
Telomerase RNP Bound and base-paired to the Telomeric Chromosome End [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Telomerase RNP:G-strand telomeric chromosome end [nucleoplasm] (Mus musculus)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
CDK2:CCNA phosphorylates TERF2 (Mus musculus)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Disassociation of Telomerase RNP and the Chromosome End (Mus musculus)
Telomerase Holoenzyme:Telomeric RNP End with Two Additional Single Stranded Telomere Repeats [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Telomeric G-strand chromosome end with two additional single strand repeats [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Elongation Of The Telomeric Chromosome End (Mus musculus)
Telomerase RNP Bound and base-paired to the Telomeric Chromosome End [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Elongation of Extended Telomeric Chromosome End (Mus musculus)
Telomerase Holoenzyme:Telomeric RNP End with Two Additional Single Stranded Telomere Repeats [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
PP6-PPP6R3 dephosphorylates TERF2 (Mus musculus)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Recruitment of Telomerase RNP to the Telomeric Chromosome End (Mus musculus)
Telomerase RNP:G-strand telomeric chromosome end [nucleoplasm] (Mus musculus)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Mus musculus)
Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Inhibition of DNA recombination at telomere (Mus musculus)
ATRX:DAXX binds to subtelomeric chromosomal regions (Mus musculus)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Telomere:Shelterin:Nucleosome:ATRX:DAXX [nucleoplasm] (Mus musculus)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Histone H3.3 deposition at telomere (Mus musculus)
Telomere:Shelterin:Nucleosome (H3F3A):ATRX:DAXX [nucleoplasm] (Mus musculus)
Telomere:Shelterin:Nucleosome (H3F3A) [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Telomere:Shelterin:Nucleosome:ATRX:DAXX [nucleoplasm] (Mus musculus)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular Senescence (Mus musculus)
DNA Damage/Telomere Stress Induced Senescence (Mus musculus)
Telomere shortening during replicative exhaustion (Mus musculus)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
DNA Repair (Mus musculus)
Base Excision Repair (Mus musculus)
Base-Excision Repair, AP Site Formation (Mus musculus)
Depurination (Mus musculus)
Cleavage of the damaged purine (Mus musculus)
NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Mus musculus)
NEIL3:AP-Telomeric DNA:Shelterin [nucleoplasm] (Mus musculus)
AP-Telomeric DNA:Shelterin [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
NEIL3:Gh-Telomeric DNA:Shelterin [nucleoplasm] (Mus musculus)
Gh-Telomeric DNA:Shelterin [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
Recognition and association of DNA glycosylase with site containing an affected purine (Mus musculus)
NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Mus musculus)
Gh-Telomeric DNA:Shelterin [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
NEIL3:Gh-Telomeric DNA:Shelterin [nucleoplasm] (Mus musculus)
Gh-Telomeric DNA:Shelterin [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
TERF2 homodimer [nucleoplasm] (Mus musculus)
Terf2 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:O35144 Terf2
Gene Names
Terf2, Trf2
Chain
chain:1-541
Reference Genes
BioGPS Gene:21750 Terf2
ENSEMBL:ENSMUSG00000031921.18 Terf2
KEGG Gene (Mus musculus):21750 Terf2
Monarch:21750 Terf2
NCBI Gene:21750 Terf2
UCSC:O35144 Terf2
Reference Transcript
RefSeq:XM_006530836.3 Terf2
RefSeq:NM_001083118.2 Terf2
RefSeq:NM_001286200.1 Terf2
Other Identifiers
10581523
108303_at
108933_at
1421147_at
1455651_at
17512716
21750
4309546
4321377
4405030
4513548
4584744
4592212
4796095
4886985
4907017
4966321
5078936
5087734
5157654
5193502
5330393
93413_at
AF003000_s_at
A_52_P391210
A_52_P427544
A_52_P580017
A_55_P2034345
A_55_P2034350
GE33788
GO:0000723
GO:0000781
GO:0000782
GO:0000783
GO:0001673
GO:0001701
GO:0003677
GO:0003691
GO:0003720
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0006278
GO:0006310
GO:0007018
GO:0007049
GO:0008089
GO:0010628
GO:0010629
GO:0016233
GO:0016604
GO:0016740
GO:0019899
GO:0031627
GO:0031848
GO:0032200
GO:0032204
GO:0032205
GO:0032206
GO:0032208
GO:0032210
GO:0032211
GO:0042162
GO:0042803
GO:0043226
GO:0044877
GO:0048856
GO:0061820
GO:0070187
GO:0070198
GO:0098505
GO:0099088
GO:0140097
GO:1904115
GO:1904354
GO:1904357
GO:1904430
GO:1905839
GO:2000773
ILMN_1247870
ILMN_2623712
mMC015594
Participates
as a component of
TERF2 homodimer [nucleoplasm] (Mus musculus)
Other forms of this molecule
Telomeric repeat-binding factor 2 [nucleoplasm]
phospho-Terf2 [nucleoplasm]
Inferred From
TERF2 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
XP_006530899.1
,
NP_001273129.1
,
NP_001076587.1
Ensembl
ENSMUSG00000031921
,
ENSMUST00000068421
,
ENSMUSP00000068948
,
ENSMUSP00000112126
,
ENSMUST00000116425
PRO
O35144
MGI
1195972
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6ZQJ5
1
DNA2 [nucleoplasm]
(R-MMU-68465)
0.576
4
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