Reactome | Cdc23 [nucleoplasm]

Cdc23 [nucleoplasm]

Stable Identifier

R-MMU-174228

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

CDC23, Q8BGZ4

Locations in the PathwayBrowser

Expand all

Cell Cycle (Mus musculus)

- Cell Cycle, Mitotic (Mus musculus)
  - Regulation of mitotic cell cycle (Mus musculus)
    - APC/C-mediated degradation of cell cycle proteins (Mus musculus)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Mus musculus)
        
        APC/C:Cdh1 polyubiquitinates SKP2 (Mus musculus)
        
        PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm] (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc23 [nucleoplasm] (Mus musculus)
        
        RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc23 [nucleoplasm] (Mus musculus)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc23 [nucleoplasm] (Mus musculus)
        
        PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm] (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc23 [nucleoplasm] (Mus musculus)
        
        RB1 recruits APC/C:Cdh1 complex to SKP2 (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc23 [nucleoplasm] (Mus musculus)
        
        RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc23 [nucleoplasm] (Mus musculus)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Mus musculus)
        
        Phosphorylation of the APC/C (Mus musculus)
        
        Free APC/C phosphorylated by Cyclin B:Cdc2 (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc23 [nucleoplasm] (Mus musculus)
        
        Free APC/C phosphorylated by Plk1 (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc23 [nucleoplasm] (Mus musculus)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Mus musculus)
        
        Degradation of multiubiquitinated Cdh1 (Mus musculus)
        
        multiubiquitinated Cdh1 associated with APC/C [nucleoplasm] (Mus musculus)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc23 [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc23 [nucleoplasm] (Mus musculus)
        
        Multiubiquitination of APC/C-associated Cdh1 (Mus musculus)
        
        multiubiquitinated Cdh1 associated with APC/C [nucleoplasm] (Mus musculus)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc23 [nucleoplasm] (Mus musculus)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc23 [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc23 [nucleoplasm] (Mus musculus)
      - Regulation of APC/C activators between G1/S and early anaphase (Mus musculus)
        
        Association of Cyclin A:Cdk2 with Cdh1 (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc23 [nucleoplasm] (Mus musculus)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc23 [nucleoplasm] (Mus musculus)
        
        Dissociation of phospho-Cdh1 from the APC/C complex (Mus musculus)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc23 [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc23 [nucleoplasm] (Mus musculus)
        
        Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Mus musculus)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc23 [nucleoplasm] (Mus musculus)
        
        Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc23 [nucleoplasm] (Mus musculus)

Cellular responses to stimuli (Mus musculus)

- Cellular responses to stress (Mus musculus)
  - Cellular Senescence (Mus musculus)
    - Senescence-Associated Secretory Phenotype (SASP) (Mus musculus)
      - CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc23 [nucleoplasm] (Mus musculus)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc23 [nucleoplasm] (Mus musculus)
      - CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Mus musculus)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc23 [nucleoplasm] (Mus musculus)
        
        Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc23 [nucleoplasm] (Mus musculus)
      - Cdh1:APC/C complex binds EHMT1:EHMT2 (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc23 [nucleoplasm] (Mus musculus)
        
        EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc23 [nucleoplasm] (Mus musculus)
      - Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Mus musculus)
        
        EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc23 [nucleoplasm] (Mus musculus)
        
        Ub-EHMT1:Ub-EHMT2:Cdh1:p-APC/C [nucleoplasm] (Mus musculus)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Mus musculus)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)
        
        Cdc23 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8BGZ4

Gene Names

Cdc23

Reference Genes

BioGPS Gene:52563 Cdc23

ENSEMBL:ENSMUSG00000024370

KEGG Gene (Mus musculus):52563 Cdc23

Monarch:52563 Cdc23

NCBI Gene:52563 Cdc23

UCSC:Q8BGZ4 Cdc23

Reference Transcript

RefSeq:NM_178347.4 Cdc23

Participates

as a component of

phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Mus musculus)

Other forms of this molecule

Cdc23 [cytosol]

Inferred From

CDC23 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_848124.1

PRO

Q8BGZ4

MGI

1098815

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12834 CDC20	3	CDC20 [cytosol] (R-HSA-141412) CDC20 [nucleoplasm] (R-HSA-174112) PolyUb-CDC20 [nucleoplasm] (R-HSA-6783069)	0.564	4
UniProt:P51955 NEK2	1	NEK2 [cytosol] (R-HSA-177329)	0.564	4
UniProt:Q9UKT4 FBXO5	6	p-FBXO5 [nucleoplasm] (R-HSA-163049) p-S145,S149-FBXO5 [nucleoplasm] (R-HSA-174220) p-S182-FBXO5 [nucleoplasm] (R-HSA-176447) FBXO5 [nucleoplasm] (R-HSA-174060) p-S145,S149-FBXO5 [cytosol] (R-HSA-174207) p-S182-FBXO5 [cytosol] (R-HSA-177324)	0.564	3
UniProt:O60566 BUB1B	1	BUB1B [cytosol] (R-HSA-141436)	0.564	3
UniProt:Q13257 MAD2L1	2	MAD2L1 [cytosol] (R-HSA-141400) Activated MAD2L1 [cytosol] (R-HSA-141447)	0.564	2

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