Reactome | CDK6 [nucleoplasm]

CDK6 [nucleoplasm]

Stable Identifier

R-MMU-141283

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

Q64261

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Transcriptional regulation by RUNX1 (Mus musculus)
      - Regulation of RUNX1 Expression and Activity (Mus musculus)
        
        CDK6 binds RUNX1 (Mus musculus)
        
        CDK6 [nucleoplasm] (Mus musculus)
        
        RUNX1,RUNX1:CBFB:CDK6 [nucleoplasm] (Mus musculus)
        
        CDK6 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q64261

Reference Genes

BioGPS Gene:12571

ENSEMBL:ENSMUSG00000040274

ENSEMBL:ENSMUSG00000040274.12

KEGG Gene (Mus musculus):12571

Monarch:12571

NCBI Gene:12571

UCSC:Q64261

Reference Transcript

RefSeq:NM_009873.3

Other Identifiers

10519324

109445_at

113777_at

12571

1435338_at

1455287_at

1460291_at

17434297

4315761

4339080

4462834

4483335

4538680

4559321

4645845

4661441

4688153

4690391

4710157

4710556

4724238

4743199

4930656

4931458

5035085

5054501

5066787

5069358

5100777

5125327

5196575

5198274

5226333

5249785

5265398

5316126

5316218

5341457

5354659

5367798

5450527

5460648

5475086

5533674

A_51_P388310

A_51_P489779

A_52_P417489

A_55_P2079630

A_55_P2736430

A_66_P113861

GE1497790

GE41727

GO:0000082

GO:0000122

GO:0000166

GO:0000278

GO:0000307

GO:0001726

GO:0001954

GO:0002244

GO:0002376

GO:0003323

GO:0003824

GO:0004672

GO:0004674

GO:0004693

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0006351

GO:0006355

GO:0006468

GO:0006974

GO:0007049

GO:0007155

GO:0007165

GO:0007219

GO:0009615

GO:0010033

GO:0010389

GO:0010468

GO:0010628

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0030097

GO:0030154

GO:0030332

GO:0033077

GO:0036211

GO:0042063

GO:0042127

GO:0042995

GO:0043226

GO:0043697

GO:0045638

GO:0045646

GO:0045656

GO:0045668

GO:0045786

GO:0048146

GO:0048856

GO:0050680

GO:0051301

GO:0060218

GO:0097132

GO:0098770

GO:0106310

GO:0140096

GO:1902036

GO:2000773

ILMN_1259714

ILMN_2474052

mMC005769

mMC008913

Participates

as an input of

CDK6 binds RUNX1 (Mus musculus)

as a component of

as a candidate of

CDK4,CDK6 [nucleoplasm] (Mus musculus)

Other forms of this molecule

CDK6 [cytosol]

phospho-p-T177-CDK6 [nucleoplasm]

Inferred From

CDK6 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_034003.1

IntEnz

2.7.11.22

Ensembl

ENSMUSG00000040274, ENSMUST00000165117, ENSMUST00000042410, ENSMUSP00000126024, ENSMUSP00000037925

PRO

Q64261

MGI

1277162

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P30282	2	Ccnd3 [cytosol] (R-MMU-68333) Ccnd3 [nucleoplasm] (R-MMU-113835)	0.564	2
UniProt:P05627 Jun	5	p-S63,S73-Jun [cytosol] (R-MMU-8868678) Jun [cytosol] (R-MMU-8868685) Jun [nucleoplasm] (R-MMU-3261183) phospho-Jun [nucleoplasm] (R-MMU-450237) Jun [nucleoplasm] (R-MMU-450250)	0.499	2
UniProt:P42227 Stat3	13	phospho-Stat3 [nucleoplasm] (R-MMU-1112554) phospho-Stat3 [cytosol] (R-MMU-914048) Stat3 [cytosol] (R-MMU-539044) phospho-Stat3 [cytosol] (R-MMU-8983130) Stat3 [cytosol] (R-MMU-914084) p-Y705-Stat3 [cytosol] (R-MMU-914034) p(Y705)-Stat3 [nucleoplasm] (R-MMU-2730582) phospho-Stat3 [cytosol] (R-MMU-539048) phospho-Stat3 [nucleoplasm] (R-MMU-9027589) phospho-Stat3 [nucleoplasm] (R-MMU-9701429) phospho-Stat3 [nucleoplasm] (R-MMU-9701435) phospho-Stat3 [cytosol] (R-MMU-8982823) phospho-Stat3 [nucleoplasm] (R-MMU-8983188)	0.499	3
UniProt:P30280	2	Ccnd2 [cytosol] (R-MMU-68340) Ccnd2 [nucleoplasm] (R-MMU-113827)	0.462	3