Reactome | Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin

Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin

Stable Identifier

R-HSA-984648

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytokinesis requires the central spindle, which forms during anaphase by the bundling of antiparallel nonkinetochore microtubules. Microtubule bundling and completion of cytokinesis require MKLP1, a kinesin-6 family member, and RACGAP1 (MgcRacGap), which contains a RhoGAP domain. These form a heterotetrameric complex known as centralspindlin. Centralspindlin, but not its individual components, strongly promotes microtubule bundling in vitro.

Literature References

PubMed ID	Title	Journal	Year
1406973	A plus-end-directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles Lombillo, VA, Kuriyama, R, McIntosh, JR, Nislow, C	Nature	1992
11782313	Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity Mishima, M, Kaitna, S, Glotzer, M	Dev Cell	2002