Reactome | SYK binds the activated BCR

SYK binds the activated BCR

Stable Identifier

R-HSA-983700

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Recruitment of SYK to the Activated B Cell Receptor

ReviewStatus

5/5

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The SYK protein tyrosine kinase binds specifically to phosphorylated immunoreceptor tyrosine-activated motifs (ITAMs) on Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) (Law et al. 1994, Saouaf et al. 1995, Rowley et al. 1995, Tsang et al. 2008). The binding activates the kinase activity of SYK (Rowley et al. 1995, Tsang et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
7538118	Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation Chao, HG, Bolen, JB, Burkhardt, AL, Rowley, RB, Matsueda, GR	J Biol Chem	1995
7592958	Reconstitution of the B cell antigen receptor signaling components in COS cells Saouaf, SJ, Mahajan, S, Bolen, JB, Fargnoli, J, Kut, SA, Rowley, RB	J Biol Chem	1995
18818202	Molecular mechanism of the Syk activation switch Shaw, D, Papp, E, Gandhi, S, Tsang, E, Giannetti, AM, Tse, JK, Dinh, M, Wang, S, Ho, H, Bradshaw, JM	J Biol Chem	2008
8163536	Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex Chandran, KA, Law, CL, Clark, EA, Weiss, A, Chan, AC, Sidorenko, SP, Edelhoff, S, Draves, KE, Disteche, CM	J Biol Chem	1994