Reactome | NPEPPS [cytosol]

NPEPPS [cytosol]

Stable Identifier

R-HSA-983056

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Puromycin-sensitive aminopeptidase, PSA_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P55786 NPEPPS

Gene Names

NPEPPS, PSA

Chain

chain:1-919

Reference Genes

BioGPS Gene:9520 NPEPPS

COSMIC (genes):NPEPPS NPEPPS

CTD Gene:9520 NPEPPS

dbSNP Gene:9520 NPEPPS

ENSEMBL:ENSG00000141279 NPEPPS

ENSEMBL_homo_sapiens_GENE:ENSG00000141279.18 NPEPPS

HGNC:7900 NPEPPS

KEGG Gene (Homo sapiens):9520 NPEPPS

Monarch:9520 NPEPPS

NCBI Gene:9520 NPEPPS

OMIM:606793 NPEPPS

UCSC:P55786 NPEPPS

Reference Transcript

Other Identifiers

11716691_a_at

11716692_x_at

11746097_a_at

11748039_s_at

11752916_s_at

16835213

201454_PM_s_at

201454_s_at

201455_PM_s_at

201455_s_at

214107_PM_x_at

214107_x_at

215090_PM_x_at

215090_x_at

2665038

2665039

3724700

3724701

3724702

3724703

3724704

3724705

3724709

3724714

3724720

3724721

3724723

3724725

3724727

3724729

3724732

3724737

3724741

3724742

3724744

3724746

3724749

3724753

3724755

3724756

3724757

3724758

3724759

3724760

3724763

3724767

3724768

3724769

3724770

3724771

3724772

3754998

3754999

3755001

3755002

3755006

3755008

3755009

3755011

3755012

3755018

3755024

3755026

3755027

3755028

39431_at

4039957

4039962

4039967

4039989

4039993

4039998

4040000

4040011

4040015

4040019

4040029

4040039

4040045

4040049

4040084

4040086

4040088

4040101

4040102

4040103

4040109

4040113

8007976

8014650

82057_at

9520

A_23_P124912

A_23_P164331

A_23_P84836

GE55226

GO:0000209

GO:0003824

GO:0004177

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005829

GO:0006508

GO:0006886

GO:0007005

GO:0008233

GO:0008237

GO:0008270

GO:0016787

GO:0036211

GO:0042277

GO:0043171

GO:0043226

GO:0046872

GO:0070006

GO:0070062

GO:0071456

GO:0140096

GO:1903955

HMNXSV003002820

Hs.293007.0.A1_3p_s_at

Hs.293007.0.A3_3p_a_at

Hs.326350.0.A1_3p_s_at

ILMN_2116127

PH_hs_0015212

TC17000609.hg

TC17002605.hg

Y07701_at

Participates

as a member of

IFN gamma stimulated aminopeptidases [cytosol] (Homo sapiens)

Inferred To

NPEPPS [cytosol] (Bos taurus)

NPEPPS [cytosol] (Canis familiaris)

NPEPPS [cytosol] (Dictyostelium discoideum)

NPEPPS [cytosol] (Drosophila melanogaster)

NPEPPS [cytosol] (Gallus gallus)

NPEPPS [cytosol] (Mus musculus)

NPEPPS [cytosol] (Rattus norvegicus)

NPEPPS [cytosol] (Saccharomyces cerevisiae)

NPEPPS [cytosol] (Schizosaccharomyces pombe)

NPEPPS [cytosol] (Sus scrofa)

NPEPPS [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001317186.1, NP_006301.3

Guide to Pharmacology - Targets

1575

OpenTargets

ENSG00000141279

GeneCards

P55786

HPA

ENSG00000141279-NPEPPS

ZINC - Substances

PSA_HUMAN

Ensembl

ENST00000677120, ENSP00000503682, ENSG00000141279, ENSP00000320324, ENST00000322157

ZINC target

P55786

PRO

P55786

Pharos - Targets

P55786

ZINC - Predictions - Purchasable

PSA_HUMAN

PDB

8SW0, 8SW1

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	17