Reactome | KCNC4 [plasma membrane]

KCNC4 [plasma membrane]

Stable Identifier

R-HSA-977458

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Potassium voltage-gated channel subfamily C member 4, KCNC4_HUMAN

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Potassium Channels (Homo sapiens)
  - Voltage gated Potassium channels (Homo sapiens)
    - Activation of voltage gated Potassium channels (Homo sapiens)
      - Octamer of Voltage gated K+ channels [plasma membrane] (Homo sapiens)
        
        Voltage gated potassium channel subunits Kv1-12 [plasma membrane] (Homo sapiens)
        
        Kv3 subunits of voltage gated potassium channels [plasma membrane] (Homo sapiens)
        
        KCNC4 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q03721 KCNC4

Gene Names

KCNC4, C1orf30

Chain

chain:1-635

Reference Genes

BioGPS Gene:3749 KCNC4

COSMIC (genes):KCNC4 KCNC4

CTD Gene:3749 KCNC4

dbSNP Gene:3749 KCNC4

ENSEMBL:ENSG00000116396 KCNC4

ENSEMBL_homo_sapiens_GENE:ENSG00000116396.15 KCNC4

HGNC:6236 KCNC4

KEGG Gene (Homo sapiens):3749 KCNC4

Monarch:3749 KCNC4

NCBI Gene:3749 KCNC4

OMIM:176265 KCNC4

UCSC:Q03721 KCNC4

Reference Transcript

Other Identifiers

11723879_a_at

11723880_a_at

11741985_a_at

16668533

208251_PM_at

208251_at

228436_PM_at

228436_at

2351295

2351296

2351297

2351298

2351299

2351300

2351301

2351302

2351325

2351326

2351329

2351336

2351337

2351338

2351339

2351340

2351341

2351342

2351343

2351344

2351345

2351346

2351347

2351348

2351349

2351350

2351351

2351370

2351371

2351372

2351375

235467_PM_s_at

235467_s_at

3749

39189_at

49987_at

50669_s_at

50670_at

72937_at

7903867

A_14_P107172

A_23_P12079

GE528597

GE564206

GE85911

GO:0005215

GO:0005216

GO:0005249

GO:0005251

GO:0005267

GO:0005515

GO:0005886

GO:0006811

GO:0006813

GO:0007268

GO:0008076

GO:0016020

GO:0023052

GO:0032590

GO:0032809

GO:0034220

GO:0034702

GO:0042734

GO:0043679

GO:0045211

GO:0051260

GO:0055085

GO:0065003

GO:0071805

HMNXSV003015717

HMNXSV003018093

Hs.106486.0.A1_3p_at

Hs.106486.0.A1_3p_x_at

Hs.107245.0.A1_3p_a_at

ILMN_1727850

ILMN_1792382

ILMN_2284013

ILMN_2388716

PH_hs_0006992

PH_hs_0007773

TC01004613.hg

TC01006402.hg

g4826789_3p_at

Participates

as a member of

Kv3 subunits of voltage gated potassium channels [plasma membrane] (Homo sapiens)

Inferred To

Shawl [plasma membrane] (Drosophila melanogaster)

Shaw [plasma membrane] (Drosophila melanogaster)

KCNC4 [plasma membrane] (Bos taurus)

KCNC4 [plasma membrane] (Canis familiaris)

KCNC4 [plasma membrane] (Gallus gallus)

KCNC4 [plasma membrane] (Sus scrofa)

Kcnc4 [plasma membrane] (Mus musculus)

Kcnc4 [plasma membrane] (Rattus norvegicus)

Homologues of KCNC4 [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_004969.2, NP_001034663.1

Guide to Pharmacology - Targets

551

OpenTargets

ENSG00000116396

HPA

ENSG00000116396-KCNC4

GeneCards

Q03721

Ensembl

ENSP00000436656, ENST00000438661, ENSP00000358802, ENSP00000393655, ENST00000469655, ENST00000369787, ENSG00000116396

PRO

Q03721

Pharos - Targets

Q03721

HMDB Protein

HMDBP10850

PDB

1B4I, 1ZTN, 1B4G

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P56817 BACE1	8	BACE1 [endoplasmic reticulum lumen] (R-HSA-6783326) 7K-BACE1 [endoplasmic reticulum lumen] (R-HSA-5693006) BACE1(22-45) [Golgi-associated vesicle lumen] (R-HSA-5693069) 7K-BACE1 [Golgi-associated vesicle lumen] (R-HSA-5693095) 7K-BACE1(46-501) [Golgi-associated vesicle lumen] (R-HSA-5693106) BACE1(46-501) [Golgi-associated vesicle lumen] (R-HSA-5693105) BACE1(46-501) [plasma membrane] (R-HSA-5692933) BACE1 [endosome membrane] (R-HSA-5692942)	0.524	3