Reactome | PHGDH [cytosol]

PHGDH [cytosol]

Stable Identifier

R-HSA-977340

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

D-3-phosphoglycerate dehydrogenase, SERA_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O43175 PHGDH

Gene Names

PHGDH, PGD, PGDH3

Chain

initiator methionine:, chain:2-533

Reference Genes

BioGPS Gene:26227 PHGDH

COSMIC (genes):PHGDH PHGDH

CTD Gene:26227 PHGDH

dbSNP Gene:26227 PHGDH

ENSEMBL:ENSG00000092621 PHGDH

ENSEMBL_homo_sapiens_GENE:ENSG00000092621.13 PHGDH

HGNC:8923 PHGDH

KEGG Gene (Homo sapiens):26227 PHGDH

Monarch:26227 PHGDH

NCBI Gene:26227 PHGDH

OMIM:606879 PHGDH

UCSC:O43175 PHGDH

Reference Transcript

RefSeq:NM_006623.3 PHGDH

Other Identifiers

11728203_a_at

16669389

201397_PM_at

201397_at

2354629

2354639

2354641

2354642

2354651

2354652

2354655

2354660

2354662

2354675

2354676

2354677

2354682

2354689

2354690

2354695

2354696

2354698

2354699

26227

34367_at

63911_at

7904433

GE81662

GO:0003824

GO:0004617

GO:0005576

GO:0005615

GO:0005829

GO:0006091

GO:0006520

GO:0006541

GO:0006544

GO:0006563

GO:0006564

GO:0006566

GO:0006790

GO:0007420

GO:0008652

GO:0009055

GO:0009448

GO:0010468

GO:0016491

GO:0016616

GO:0019530

GO:0021510

GO:0021782

GO:0021915

GO:0022008

GO:0022900

GO:0030060

GO:0030154

GO:0031175

GO:0043226

GO:0048856

GO:0051287

GO:0070062

GO:0070314

HMNXSV003047523

ILMN_1704537

PH_hs_0000404

TC01001043.hg

g5729973_3p_at

Participates

as a component of

PHGDH tetramer [cytosol] (Homo sapiens)

Inferred To

LOC119863969 [cytosol] (Canis familiaris)

phgdh [cytosol] (Xenopus tropicalis)

GH26 [cytosol] (Drosophila melanogaster)

phdh-1 [cytosol] (Caenorhabditis elegans)

LOC119863976 [cytosol] (Canis familiaris)

PHGDH [cytosol] (Bos taurus)

PHGDH [cytosol] (Mus musculus)

PHGDH [cytosol] (Rattus norvegicus)

PHGDH [cytosol] (Sus scrofa)

Homologues of PHGDH [cytosol] (Canis familiaris)

Cross References

RefSeq

NP_006614.2

OpenTargets

ENSG00000092621

IntEnz

1.1.1.37, 1.1.1.399, 1.1.1.95

HPA

ENSG00000092621-PHGDH

GeneCards

O43175

Ensembl

ENSP00000493382, ENST00000641023, ENSP00000493175, ENST00000641597, ENSG00000092621

PRO

O43175

Pharos - Targets

O43175

Orphanet

15084

HMDB Protein

HMDBP00922

PDB

6CWA, 6RJ5, 7DKM, 6RJ2, 6PLG, 2G76, 5OFW, 5OFM, 7CVP, 6RIH, 5OFV, 6RJ3, 6PLF, 5NZO, 6RJ6, 5NZQ, 5NZP, 5N6C, 5N53, 7EWH, 7VA1

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	12
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	3
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	4
UniProt:P11440 Cdk1	11	phospho-p-T161-CDK1 [nucleoplasm] (R-MMU-170066) phospho-p-T14,Y15,T161-CDK1 [nucleoplasm] (R-MMU-170074) phospho-p-T161-CDK1 [cytosol] (R-MMU-157415) phospho-p-T14,Y15,T161-CDK1 [cytosol] (R-MMU-170071) CDK1 [cytosol] (R-MMU-170075) phospho-p-T14-CDK1 [cytosol] (R-MMU-170064) phospho-p-T14-CDK1 [nucleoplasm] (R-MMU-170045) Cdk1 [nucleoplasm] (R-MMU-1362302) phospho-p-T14,T161-CDK1 [nucleoplasm] (R-MMU-170078) phospho-p-Y4-CDK1 [cytosol] (R-MMU-9836187) CDK1 [endoplasmic reticulum membrane] (R-MMU-264424)	0.499	2

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