Reactome | ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens

ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens

Stable Identifier

R-HSA-977071

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi lumen, Golgi membrane

Synonyms

Sialyltransferase I can add sialic acid to the Tn antigen at the alpha 6 position

ReviewStatus

5/5

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ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens

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Beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1) transfers sialic acid (Neu5Ac) from the donor CMP-Neu5Ac to galactose-containing acceptor substrates such as Tn antigens (Stamenkovic et al. 1990, Marcos et al. 2004). The resultant sialyl Tn antigens are highly expressed in several human carcinomas and are associated with carcinoma aggressiveness and poor prognosis (Sewell et al. 2006, Lakshmanan et al. 2021).

Literature References

PubMed ID	Title	Journal	Year
15466199	Role of the human ST6GalNAc-I and ST6GalNAc-II in the synthesis of the cancer-associated sialyl-Tn antigen Almeida, R, Costa, J, Morais, V, Clausen, H, Kihlberg, J, Grandela, C, Reis, CA, Samyn-Petit, B, Marcos, NT, Cruz, A, Harduin-Lepers, A, Pinho, S, Silva, F	Cancer Res	2004
2373995	The B cell antigen CD75 is a cell surface sialytransferase Blomhoff, HK, Funderud, S, Stamenkovic, I, Smeland, EB, Asheim, HC, Deggerdal, A	J Exp Med	1990
16319059	The ST6GalNAc-I sialyltransferase localizes throughout the Golgi and is responsible for the synthesis of the tumor-associated sialyl-Tn O-glycan in human breast cancer Burchell, J, Bäckström, M, Karlsson, H, Sewell, R, Gätgens, J, Hansson, GC, Noll, T, Gschmeissner, S, Dalziel, M, Taylor-Papadimitriou, J, Clausen, H	J Biol Chem	2006