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UBR1 [cytosol]
Stable Identifier
R-HSA-976040
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase UBR1, UBR1_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBR1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBR1 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBR1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBR1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBR1 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBR1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBR1 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBR1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBR1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBR1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IWV7 UBR1
Gene Names
UBR1
Chain
initiator methionine:, chain:2-1749
Reference Genes
BioGPS Gene:197131 UBR1
COSMIC (genes):UBR1 UBR1
CTD Gene:197131 UBR1
dbSNP Gene:197131 UBR1
ENSEMBL:ENSG00000159459 UBR1
ENSEMBL_homo_sapiens_GENE:ENSG00000159459.12 UBR1
HGNC:16808 UBR1
Monarch:197131 UBR1
NCBI Gene:197131 UBR1
OMIM:605981 UBR1
UCSC:Q8IWV7 UBR1
Reference Transcript
RefSeq:NM_174916.2 UBR1
Other Identifiers
11720726_at
11720727_at
11720728_at
16807996
197131
226921_PM_at
226921_at
238528_PM_at
238528_at
3620882
3620883
3620884
3620885
3620886
3620887
3620888
3620889
3620890
3620892
3620895
3620896
3620897
3620898
3620901
3620902
3620903
3620904
3620905
3620907
3620908
3620909
3620910
3620911
3620913
3620915
3620916
3620917
3620918
3620919
3620920
3620921
3620923
3620924
3620925
3620927
3620928
3620929
3620930
3620931
3620932
3620933
3620934
3620935
3620936
3620937
3620938
3620939
3620940
3620941
3620942
3620944
3620946
3620947
3620948
3620950
3620951
3620957
44128_at
48354_at
7987981
A_23_P152066
A_23_P300770
A_24_P102203
GE87037
GE87038
GO:0000151
GO:0000502
GO:0003824
GO:0004842
GO:0005515
GO:0005737
GO:0005829
GO:0006511
GO:0008270
GO:0016567
GO:0016740
GO:0023052
GO:0030163
GO:0032007
GO:0036211
GO:0046872
GO:0061630
GO:0070728
GO:0071233
GO:0071596
GO:0140096
HMNXSV003002728
Hs.28113.0.A1_3p_at
Hs.293477.0.A1_3p_at
ILMN_1795964
PH_hs_0022597
TC15001271.hg
TC15002506.hg
Participates
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
UBR1 [cytosol]
(Bos taurus)
UBR1 [cytosol]
(Canis familiaris)
UBR1 [cytosol]
(Gallus gallus)
UBR1 [cytosol]
(Saccharomyces cerevisiae)
UBR1 [cytosol]
(Sus scrofa)
ubr11 [cytosol]
(Schizosaccharomyces pombe)
ubr-1 [cytosol]
(Caenorhabditis elegans)
ubr1 [cytosol]
(Schizosaccharomyces pombe)
ubr1 [cytosol]
(Xenopus tropicalis)
Homologues of UBR1 [cytosol]
(Saccharomyces cerevisiae)
Homologues of UBR1 [cytosol]
(Schizosaccharomyces pombe)
UBR2 [cytosol]
(Saccharomyces cerevisiae)
Ubr1 [cytosol]
(Drosophila melanogaster)
Ubr1 [cytosol]
(Mus musculus)
Ubr1 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_777576.1
OpenTargets
ENSG00000159459
IntEnz
2.3.2.27
GeneCards
Q8IWV7
HPA
ENSG00000159459-UBR1
Ensembl
ENST00000290650
,
ENSG00000159459
,
ENSP00000290650
PRO
Q8IWV7
Pharos - Targets
Q8IWV7
Orphanet
15681
PDB
5TDC
,
3NY1
HMDB Protein
HMDBP09268
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UBS4 DNAJB11
1
DNAJB11 [endoplasmic reticulum lumen]
(R-HSA-381040)
0.553
2
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