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KLHL20 [cytosol]
Stable Identifier
R-HSA-976032
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Kelch-like protein 20, KLH20_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL20 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL20 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL20 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL20 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL20 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL20 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL20 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL20 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL20 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL20 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL20 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL20 [cytosol] (Homo sapiens)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL20 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL20 [cytosol] (Homo sapiens)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL20 [cytosol] (Homo sapiens)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
NEDD8-CUL3:RBX1:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL20 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y2M5 KLHL20
Gene Names
KLHL20, KLEIP, KLHLX
Chain
chain:1-609
Reference Genes
BioGPS Gene:27252 KLHL20
COSMIC (genes):KLHL20 KLHL20
CTD Gene:27252 KLHL20
dbSNP Gene:27252 KLHL20
ENSEMBL:ENSG00000076321 KLHL20
HGNC:25056 KLHL20
KEGG Gene (Homo sapiens):27252 KLHL20
Monarch:27252 KLHL20
NCBI Gene:27252 KLHL20
OMIM:617679 KLHL20
UCSC:Q9Y2M5 KLHL20
Reference Transcript
RefSeq:XM_005245093.3 KLHL20
RefSeq:NM_014458.3 KLHL20
Other Identifiers
0004200091
11730786_a_at
11730787_at
11746293_a_at
16673961
204176_at
204177_s_at
210635_s_at
2367794
2367795
2367801
2367807
2367808
2367816
2367817
2367819
2367820
2367822
2367826
2367827
2367829
2367832
2367833
2367834
25034
27252
37150_at
43075_r_at
53704
5YQ4
6GY5
7907445
A0A024R940
A_14_P128697
A_23_P160283
A_33_P3243707
AAH63418
AB026190
AJ844466
AK001430
AK300755
AL109921
BAA77027
BAG50912
BAG62422
BC063418
BX248409
CAH59617
CCDS1310
CH471067
EAW90953
EAW90955
ENSG00000076321
ENSP00000209884
ENST00000209884
ENST00000209884.4
EntrezGene:27252
EntrezGene:KLHL20
g13528917_3p_a_at
g13677223_3p_a_at
GE55787
GO:0003674
GO:0003779
GO:0004842
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005794
GO:0005802
GO:0005829
GO:0005856
GO:0006464
GO:0006810
GO:0006895
GO:0007010
GO:0008092
GO:0008150
GO:0008219
GO:0009056
GO:0015031
GO:0015629
GO:0016192
GO:0016567
GO:0016605
GO:0019964
GO:0030424
GO:0030425
GO:0031463
GO:0032991
GO:0035455
GO:0042995
GO:0043066
GO:0043161
GO:0043226
GO:0043687
GO:0048471
GO:1990390
HGNC:25056
HPA025034
HPA053704
Hs.106290.0.S2_3p_at
ILMN_1756525
IPR000210
IPR006652
IPR011333
IPR011705
IPR015915
IPR017096
KLHL20
KLHL20-201
MIM:617679
NM_014458
NP_055273
PF00651
PF01344
PF07707
PH_hs_0005916
PR00501
SM00225
SM00612
SM00875
TC01001513.hg
UPI0000227E1A
XM_005245093
XM_011509420
XM_017001052
XM_017001053
XM_017001054
XM_024446468
XM_024446472
XP_005245150
XP_011507722
XP_016856541
XP_016856542
XP_016856543
XP_024302236
XP_024302240
XR_001737119
XR_001737121
XR_921766
XR_921767
Participant Of
hasMember
BTB proteins [cytosol]
Inferred To
KLHL20 [cytosol] (Bos taurus)
KLHL20 [cytosol] (Caenorhabditis elegans)
KLHL20 [cytosol] (Danio rerio)
KLHL20 [cytosol] (Dictyostelium discoideum)
KLHL20 [cytosol] (Drosophila melanogaster)
KLHL20 [cytosol] (Gallus gallus)
KLHL20 [cytosol] (Mus musculus)
KLHL20 [cytosol] (Rattus norvegicus)
KLHL20 [cytosol] (Sus scrofa)
KLHL20 [cytosol] (Xenopus tropicalis)
Cross References
RefSeq
NP_055273.2
,
XP_005245150.1
OpenTargets
ENSG00000076321
GeneCards
Q9Y2M5
PRO
Q9Y2M5
PDB
5YQ4
,
6GY5
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P29590 PML
5
SUMO2-K65,K160,K490-PML [nucleoplasm]
(R-HSA-3000423)
SUMO3-K65,K160,K490-PML [nucleoplasm]
(R-HSA-3000386)
SUMO1-K65,160,490-PML [nucleoplasm]
(R-HSA-3000440)
PML [nucleoplasm]
(R-HSA-1031706)
PML [cytosol]
(R-HSA-5624327)
0.744
9
UniProt:Q96LA8 PRMT6
1
PRMT6 [nucleoplasm]
(R-HSA-5226884)
0.508
2
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