Reactome | FBXO44 [cytosol]

FBXO44 [cytosol]

Stable Identifier

R-HSA-976031

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

F-box only protein 44, FBX44_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Neddylation (Homo sapiens)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO44 [cytosol] (Homo sapiens)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO44 [cytosol] (Homo sapiens)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO44 [cytosol] (Homo sapiens)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO44 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO44 [cytosol] (Homo sapiens)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO44 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO44 [cytosol] (Homo sapiens)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO44 [cytosol] (Homo sapiens)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO44 [cytosol] (Homo sapiens)
    - MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO44 [cytosol] (Homo sapiens)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO44 [cytosol] (Homo sapiens)
    - NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO44 [cytosol] (Homo sapiens)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO44 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9H4M3 FBXO44

Gene Names

FBXO44, FBG3, FBX30, FBX44, FBX6A, FBXO6A

Chain

chain:1-255

Reference Genes

BioGPS Gene:93611 FBXO44

COSMIC (genes):FBXO44 FBXO44

CTD Gene:93611 FBXO44

dbSNP Gene:93611 FBXO44

ENSEMBL:ENSG00000132879 FBXO44

ENSEMBL_homo_sapiens_GENE:ENSG00000132879.14 FBXO44

HGNC:24847 FBXO44

KEGG Gene (Homo sapiens):93611 FBXO44

Monarch:93611 FBXO44

NCBI Gene:93611 FBXO44

OMIM:609111 FBXO44

UCSC:Q9H4M3 FBXO44

Reference Transcript

Other Identifiers

11736264_a_at

11736265_x_at

11736433_a_at

11741033_a_at

11741034_x_at

11747390_a_at

11747391_x_at

11753460_a_at

11753461_x_at

16659021

222861_PM_x_at

222861_x_at

223517_PM_at

223517_at

2320348

2320349

2320350

2320351

2320352

2320353

2320355

2320356

2320358

2320359

2320363

2320364

2320365

2320366

2320367

2320368

2320369

2320370

2320371

2320373

2320375

46603_at

7897714

93611

A_23_P200637

A_33_P3237235

GE85478

GO:0003824

GO:0005515

GO:0005737

GO:0005829

GO:0006516

GO:0010498

GO:0016740

GO:0019005

GO:0030163

GO:0030433

GO:0031146

GO:0061630

GO:0140096

GO:1901135

HMNXSV003012321

Hs.321687.0.S2_3p_at

ILMN_1651597

ILMN_1689380

ILMN_1732182

ILMN_2325625

PH_hs_0029737

TC01000144.hg

Participates

as a member of

F-box protein [cytosol] (Homo sapiens)

as a candidate of

E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)

Inferred To

Homologues of FBXO44 [cytosol] (Danio rerio)

Fbxo44 [cytosol] (Mus musculus)

Fbxo44 [cytosol] (Rattus norvegicus)

si:rp71-1k13.8 [cytosol] (Danio rerio)

FBXO44 [cytosol] (Bos taurus)

FBXO44 [cytosol] (Caenorhabditis elegans)

FBXO44 [cytosol] (Canis familiaris)

FBXO44 [cytosol] (Danio rerio)

FBXO44 [cytosol] (Gallus gallus)

FBXO44 [cytosol] (Sus scrofa)

LOC101731802 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001291719.1, XP_016858333.1, NP_904320.1, NP_149438.2, XP_006711108.1, NP_904319.1, NP_001014765.1, XP_016858332.1, NP_001291720.1

OpenTargets

ENSG00000132879

GeneCards

Q9H4M3

HPA

ENSG00000132879-FBXO44

Ensembl

ENST00000251546, ENSP00000365951, ENSP00000365961, ENSP00000251546, ENSP00000251547, ENSG00000132879, ENST00000251547, ENSP00000365953, ENST00000376762, ENST00000376770, ENST00000376760

PRO

Q9H4M3

Pharos - Targets

Q9H4M3

PDB

5B4N, 3WSO

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63208 SKP1	2	SKP1 [nucleoplasm] (R-HSA-187538) SKP1 [cytosol] (R-HSA-174150)	0.743	5

Cite Us!