Reactome | LRR1 [cytosol]

LRR1 [cytosol]

Stable Identifier

R-HSA-976019

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Peptidylprolyl isomerase-like 5, PPIL5, LLR1_HUMAN

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Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Neddylation (Homo sapiens)
    - AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Homo sapiens)
      - NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        LRR1 [cytosol] (Homo sapiens)
      - NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        NEDD8-CRL2 E3 ligase complex [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        LRR1 [cytosol] (Homo sapiens)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        LRR1 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        LRR1 [cytosol] (Homo sapiens)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        LRR1 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        LRR1 [cytosol] (Homo sapiens)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        LRR1 [cytosol] (Homo sapiens)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        NEDD8-CRL2 E3 ligase complex [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        LRR1 [cytosol] (Homo sapiens)
    - NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        LRR1 [cytosol] (Homo sapiens)
      - NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        LRR1 [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
21074724	CRL2(LRR-1) targets a CDK inhibitor for cell cycle control in C. elegans and actin-based motility regulation in human cells Starostina, NG, McGuirk, MA, Simpliciano, JM, Kipreos, ET	Dev. Cell	2010

External Reference Information

External Reference

UniProt:Q96L50 LRR1

Gene Names

LRR1, PPIL5

Chain

chain:1-414

Reference Genes

BioGPS Gene:122769 LRR1

COSMIC (genes):LRR1 LRR1

CTD Gene:122769 LRR1

dbSNP Gene:122769 LRR1

ENSEMBL:ENSG00000165501 LRR1

ENSEMBL_homo_sapiens_GENE:ENSG00000165501.17 LRR1

HGNC:19742 LRR1

KEGG Gene (Homo sapiens):122769 LRR1

Monarch:122769 LRR1

NCBI Gene:122769 LRR1

OMIM:609193 LRR1

UCSC:Q96L50 LRR1

Reference Transcript

Other Identifiers

11744306_a_at

122769

16783905

235113_PM_at

235113_at

3534810

3534811

3534812

3534825

3534827

3534833

3534834

3534835

3534836

59759_i_at

59761_r_at

70164_at

7974198

A_14_P103786

A_23_P88362

A_24_P13533

A_33_P3253707

A_33_P3286208

GE62192

GO:0005515

GO:0005634

GO:0005829

GO:0007165

GO:0016567

GO:0023052

GO:0036211

GO:0043226

HMNXSV003056901

Hs.179805.0.A1_3p_at

Hs.214186.0.A1_3p_s_at

ILMN_1715616

ILMN_1778890

ILMN_2293167

ILMN_2411608

PH_hs_0026290

TC14001675.hg

Participates

as a member of

CUL2-box protein [cytosol] (Homo sapiens)

as a candidate of

E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)

Inferred To

Lrr1 [cytosol] (Mus musculus)

Lrr1 [cytosol] (Rattus norvegicus)

LRR1 [cytosol] (Bos taurus)

LRR1 [cytosol] (Canis familiaris)

LRR1 [cytosol] (Gallus gallus)

LRR1 [cytosol] (Sus scrofa)

Lrr47 [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_689542.2, NP_982292.1

OpenTargets

ENSG00000165501

GeneCards

Q96L50

HPA

ENSG00000165501-LRR1

Ensembl

ENSG00000165501, ENST00000298288, ENST00000318317, ENSP00000315628, ENSP00000298288

PRO

Q96L50

Pharos - Targets

Q96L50

PDB

7PLO

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