Reactome | LRRC41 [cytosol]

LRRC41 [cytosol]

Stable Identifier

R-HSA-976015

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Leucine-rich repeat-containing protein 41, LRC41_HUMAN, MUF1

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Neddylation (Homo sapiens)
    - AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Homo sapiens)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        LRRC41 [cytosol] (Homo sapiens)
      - NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        LRRC41 [cytosol] (Homo sapiens)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        LRRC41 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        LRRC41 [cytosol] (Homo sapiens)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        LRRC41 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        LRRC41 [cytosol] (Homo sapiens)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        LRRC41 [cytosol] (Homo sapiens)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        LRRC41 [cytosol] (Homo sapiens)
    - NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        LRRC41 [cytosol] (Homo sapiens)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        LRRC41 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15345 LRRC41

Gene Names

LRRC41, MUF1, PP7759

Chain

chain:1-812

Reference Genes

BioGPS Gene:10489 LRRC41

COSMIC (genes):LRRC41 LRRC41

CTD Gene:10489 LRRC41

dbSNP Gene:10489 LRRC41

ENSEMBL:ENSG00000132128 LRRC41

ENSEMBL_homo_sapiens_GENE:ENSG00000132128.18 LRRC41

HGNC:16917 LRRC41

KEGG Gene (Homo sapiens):10489 LRRC41

Monarch:10489 LRRC41

NCBI Gene:10489 LRRC41

OMIM:618753 LRRC41

UCSC:Q15345 LRRC41

Reference Transcript

RefSeq:NM_006369.4 LRRC41

Other Identifiers

10489

11747650_a_at

11754553_a_at

1555831_PM_s_at

1555831_s_at

16686611

201932_PM_at

201932_at

2410577

2410578

2410579

2410580

2410581

2410582

2410584

2410586

2410587

2410588

2410589

2410593

2410594

2410595

2410596

2410597

2410601

2410602

2410606

2410607

2410608

2410609

2410610

40807_at

42148_at

75933_at

7915827

A_33_P3289222

GE60104

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0016020

GO:0016567

GO:0036211

GO:0042802

GO:0043226

HMNXSV003004657

Hs2Affx.1.474.A1_3p_s_at

ILMN_1712755

PH_hs_0022592

TC01002618.hg

X86018_at

g5453747_3p_at

Participates

as a member of

as a component of

RBX1:CUL5:EloB/C:LRRC41 [cytosol] (Homo sapiens)

as a candidate of

E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)

Inferred To

Ghost homologue of LRRC41 [cytosol] (Caenorhabditis elegans)

Ghost homologue of LRRC41 [cytosol] (Drosophila melanogaster)

Lrrc41 [cytosol] (Mus musculus)

Lrrc41 [cytosol] (Rattus norvegicus)

lrrc41 [cytosol] (Xenopus tropicalis)

LRRC41 [cytosol] (Bos taurus)

LRRC41 [cytosol] (Canis familiaris)

LRRC41 [cytosol] (Gallus gallus)

LRRC41 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_006360.3

OpenTargets

ENSG00000132128

HPA

ENSG00000132128-LRRC41

GeneCards

Q15345

Ensembl

ENSG00000132128, ENST00000617190, ENST00000343304, ENSP00000343298, ENSP00000477792

PRO

Q15345

Pharos - Targets

Q15345

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