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HECTD3 [cytosol]
Stable Identifier
R-HSA-975991
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase HECTD3, HECD3_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECTD3 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECTD3 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECTD3 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECTD3 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECTD3 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECTD3 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECTD3 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECTD3 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECTD3 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECTD3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q5T447 HECTD3
Gene Names
HECTD3
Chain
initiator methionine:, chain:2-861
Reference Genes
BioGPS Gene:79654 HECTD3
COSMIC (genes):HECTD3 HECTD3
CTD Gene:79654 HECTD3
dbSNP Gene:79654 HECTD3
ENSEMBL:ENSG00000126107 HECTD3
ENSEMBL_homo_sapiens_GENE:ENSG00000126107.15 HECTD3
HGNC:26117 HECTD3
KEGG Gene (Homo sapiens):79654 HECTD3
Monarch:79654 HECTD3
NCBI Gene:79654 HECTD3
OMIM:618638 HECTD3
UCSC:Q5T447 HECTD3
Reference Transcript
RefSeq:NM_024602.5 HECTD3
Other Identifiers
11749707_a_at
11754948_a_at
16686345
218632_PM_at
218632_at
2409972
2409973
2409974
2409976
2409978
2409979
2409980
2409983
2409984
2409987
2409989
2409990
2409992
2409993
2409994
2409995
2409996
2409997
2409999
2410000
2410001
2410002
2410003
2410004
2410005
2410006
2410007
51112_at
7915659
79654
A_23_P149221
GE62234
GO:0003824
GO:0004842
GO:0005515
GO:0005737
GO:0016567
GO:0016740
GO:0019905
GO:0030163
GO:0036211
GO:0043161
GO:0048471
GO:0140096
HMNXSV003016016
ILMN_1656902
PH_hs_0031101
TC01002604.hg
g13375804_3p_at
Participates
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
hectd3 [cytosol]
(Xenopus tropicalis)
HECTD3 [cytosol]
(Bos taurus)
HECTD3 [cytosol]
(Canis familiaris)
HECTD3 [cytosol]
(Gallus gallus)
HECTD3 [cytosol]
(Sus scrofa)
Hectd3 [cytosol]
(Mus musculus)
Hectd3 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_078878.3
OpenTargets
ENSG00000126107
HPA
ENSG00000126107-HECTD3
GeneCards
Q5T447
Ensembl
ENST00000372172
,
ENSG00000126107
,
ENSP00000361241
,
ENSP00000361245
,
ENST00000372168
PRO
Q5T447
Pharos - Targets
Q5T447
Orphanet
29101
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60437 PPL
2
PPL [cytosol]
(R-HSA-6810850)
PPL [cornified envelope]
(R-HSA-8847709)
0.556
3
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