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RNF41 [cytosol]
Stable Identifier
R-HSA-975977
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
NRDP1, E3 ubiquitin-protein ligase NRDP1, RNF41_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q6FHY5 Q6FHY5
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB2 (Homo sapiens)
Downregulation of ERBB2 signaling (Homo sapiens)
Downregulation of ERBB2:ERBB3 signaling (Homo sapiens)
Deubiquitination of RNF41 by P-USP8 (Homo sapiens)
RNF41 [cytosol] (Homo sapiens)
ERBB3 binds RNF41 ubiquitin ligase (Homo sapiens)
RNF41 [cytosol] (Homo sapiens)
RNF41 binds neuregulin-activated ERBB3 (Homo sapiens)
RNF41 [cytosol] (Homo sapiens)
RNF41 ubiquitinates ERBB3 (Homo sapiens)
RNF41 [cytosol] (Homo sapiens)
RNF41 ubiquitinates activated ERBB3 (Homo sapiens)
RNF41 [cytosol] (Homo sapiens)
Self-ubiquitination of RNF41 (Homo sapiens)
RNF41 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H4P4 RNF41
Gene Names
RNF41, FLRF, NRDP1, SBBI03
Chain
chain:1-317
Reference Genes
BioGPS Gene:10193 RNF41
COSMIC (genes):RNF41 RNF41
CTD Gene:10193 RNF41
dbSNP Gene:10193 RNF41
ENSEMBL:ENSG00000181852 RNF41
HGNC:18401 RNF41
KEGG Gene (Homo sapiens):10193 RNF41
Monarch:10193 RNF41
NCBI Gene:10193 RNF41
UCSC:Q9H4P4 RNF41
Reference Transcript
RefSeq:XM_011537734.2 RNF41
RefSeq:NM_194359.2 RNF41
RefSeq:NM_001242826.1 RNF41
RefSeq:NM_194358.2 RNF41
RefSeq:XM_011537735.2 RNF41
RefSeq:NM_005785.3 RNF41
RefSeq:XM_005268561.4 RNF41
Other Identifiers
0005910092
0005910458
10193
11721953_a_at
11721954_s_at
11755859_a_at
16765945
16812
201961_s_at
201962_s_at
235459_at
2FZP
2GWF
3457520
3457522
3457524
3457525
3457526
3457527
3457528
3457529
3457530
3457531
3457535
3457536
3457537
3457538
3457540
3457541
3457542
3457543
3457544
40047_at
75112_at
7964021
A0A024RB33
A_23_P98884
A_24_P244470
A_24_P630875
AAC27647
AAG01988
AAH32637
AC073896
AF077599
AK314811
AY007109
BAG37335
BC024284
BC032637
CCDS8909
CCDS8910
CH471054
EAW96909
EAW96910
EAW96911
ENSG00000181852
ENSP00000342755
ENSP00000377581
ENSP00000447303
ENSP00000484671
ENST00000345093
ENST00000345093.8
ENST00000394013
ENST00000394013.6
ENST00000552656
ENST00000552656.5
ENST00000615206
ENST00000615206.4
EntrezGene:10193
EntrezGene:RNF41
F8VNZ6
F8VSB6
F8VSE5
F8VSP7
F8VVY2
g5032070_3p_a_at
GE54704
GE684812
GE827543
GO:0000209
GO:0002376
GO:0003674
GO:0004842
GO:0005128
GO:0005135
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005783
GO:0005829
GO:0006464
GO:0006914
GO:0006915
GO:0007005
GO:0007165
GO:0008150
GO:0008219
GO:0008270
GO:0008283
GO:0008285
GO:0009056
GO:0009058
GO:0010468
GO:0010498
GO:0016567
GO:0016740
GO:0017160
GO:0019899
GO:0019904
GO:0030154
GO:0030336
GO:0030971
GO:0034641
GO:0040011
GO:0043167
GO:0043226
GO:0043408
GO:0045619
GO:0045637
GO:0045732
GO:0046872
GO:0048471
GO:0048856
GO:0048870
GO:0051091
GO:0051865
GO:0051896
GO:0061630
GO:0071782
GO:0097191
GO:1901525
GO:2000114
GO:2000377
GO:2000379
HGNC:18401
HPA016812
Hs.136316.0.A1_3p_at
Hs.153639.0.S1_3p_a_at
ILMN_1700345
ILMN_1808095
IPR001841
IPR008974
IPR013010
IPR013083
IPR015036
IPR017907
IPR037255
NM_001242826
NM_005785
NM_194358
NM_194359
NP_001229755
NP_005776
NP_919339
NP_919340
PF08941
PF13923
PH_hs_0040605
RNF41
RNF41-201
RNF41-202
RNF41-211
RNF41-212
SM00184
TC12001598.hg
TC12002908.hg
UPI000006F47F
UPI00001D6A04
XM_005268561
XM_011537734
XM_011537735
XP_005268618
XP_011536036
XP_011536037
XR_002957281
Participant Of
hasCandidate
E3 ligases in proteasomal degradation [cytosol]
output
Deubiquitination of RNF41 by P-USP8
RNF41 ubiquitinates activated ERBB3
RNF41 ubiquitinates ERBB3
hasComponent
ERBB3:RNF41 [plasma membrane]
NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41 [plasma membrane]
Ub-RNF41 [cytosol]
input
ERBB3 binds RNF41 ubiquitin ligase
RNF41 binds neuregulin-activated ERBB3
Self-ubiquitination of RNF41
Inferred To
RNF41 [cytosol] (Bos taurus)
RNF41 [cytosol] (Canis familiaris)
RNF41 [cytosol] (Danio rerio)
RNF41 [cytosol] (Dictyostelium discoideum)
RNF41 [cytosol] (Drosophila melanogaster)
RNF41 [cytosol] (Gallus gallus)
RNF41 [cytosol] (Mus musculus)
RNF41 [cytosol] (Rattus norvegicus)
RNF41 [cytosol] (Sus scrofa)
RNF41 [cytosol] (Xenopus tropicalis)
Cross References
RefSeq
NP_005776.1
,
XP_011536036.1
,
XP_011536037.1
,
NP_919339.1
,
XP_005268618.1
,
NP_919340.1
,
NP_001229755.1
OpenTargets
ENSG00000181852
IntEnz
2.3.2.27
GeneCards
Q9H4P4
PRO
Q9H4P4
PDB
2GWF
,
2FZP
Interactors (20)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q99614 TTC1
0.818
11
UniProt:Q9NWX5 ASB6
1
ASB6 [cytosol]
(R-HSA-975412)
0.766
6
UniProt:P35249 RFC4
1
RFC4 [nucleoplasm]
(R-HSA-68429)
0.764
6
UniProt:Q8N1B4 VPS52
1
VPS52 [trans-Golgi network membrane]
(R-HSA-6811029)
0.696
5
UniProt:Q86U28 ISCA2
1
ISCA2 [mitochondrial matrix]
(R-HSA-5691207)
0.696
5
UniProt:Q9NX04 CA109
0.696
5
UniProt:Q9H4P4 RNF41
1
RNF41 [cytosol]
(R-HSA-975977)
0.668
3
UniProt:O15049 N4BP3
0.621
3
UniProt:Q9UHY7 ENOPH1
1
ENOPH1 [cytosol]
(R-HSA-1237187)
0.621
5
UniProt:Q7LG56 RRM2B
1
RRM2B [cytosol]
(R-HSA-111792)
0.556
3
UniProt:Q9NSB8 HOMER2
1
HOMER2 [cytosol]
(R-HSA-6794251)
0.556
3
UniProt:Q66PJ3-3 ARL6IP4
0.556
3
UniProt:Q9BRK4 LZTS2
0.556
3
UniProt:P49723 RIR4
0.556
3
UniProt:A0A0C4DG62 A0A0C4DG62
0.488
2
UniProt:Q9GZT4 SRR
1
PXLP-K56-SRR [cytosol]
(R-HSA-9014764)
0.488
4
UniProt:Q6FHY5 Q6FHY5
0.488
2
UniProt:Q8N3F0 MTURN
0.488
2
UniProt:P54725 RAD23A
1
RAD23A [nucleoplasm]
(R-HSA-5688076)
0.488
2
UniProt:Q8N8B7-2 TCEANC
0.488
2
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