IRAK4 autophosphorylation within the complex activated TLR:MyD88

Stable Identifier
R-HSA-975865
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Escherichia coli
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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IRAK4 autophosphorylation within the complex activated TLR:MyD88
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IRAK4 is activated by autophosphorylation at 3 positions within the kinase activation loop, Thr-342, Thr-345 and Ser-346.
Literature References
PubMed ID Title Journal Year
17485511 Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling

Takeuchi, O, Yamamoto, M, Sato, S, Jung, A, Akira, S, Matsui, K, Kato, H, Uematsu, S, Kawagoe, T

J Exp Med 2007
17141195 Regulation of IRAK-4 kinase activity via autophosphorylation within its activation loop

Dahlstrand, E, Wang, A, Ocain, TD, Li, Z, Addona, T, Xu, Y, Lu, C, Dorsch, M, Keshishian, H, Parsons, TF, Li, P, Jaffee, B, Cheng, H

Biochem Biophys Res Commun 2007
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane]

Physical Entity
IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Autophosphorylation of IRAK4 bound to activated TLR5 or 15 (Gallus gallus)
Authored
Shamovsky, V  (2010-10-06)
Reviewed
Li, L  (2011-08-04)
Gillespie, ME  (2011-02-10)
Created
Shamovsky, V  (2010-10-06)
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