Reactome | Miro GTPase Cycle

Miro GTPase Cycle

Stable Identifier

R-HSA-9715370

DOI

10.3180/R-HSA-9715370.1

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Miro GTPases are a separate family of Ras-related GTPases that are sometimes included in the atypical RHO GTPases group, but are phylogenetically distinct from the Rho family (Jaffe and Hall 2005; Boureux et al. 2007; Devine et al. 2016; Liu et al. 2017). Miro GTPases possess an additional GTPase domain more closely related to Rheb (Klosowiak et al. 2013). Miro family of RAS-like GTPases includes two members, RHOT1 and RHOT2. RHOT1 and RHOT2 regulate the movement of mitochondria (Schwarz 2013; Devine et al. 2016) and peroxisomes (Castro et al. 2018, Okumoto et al. 2018, Covill-Cooke et al. 2020).

Literature References

PubMed ID	Title	Journal	Year
24071720	Structural coupling of the EF hand and C-terminal GTPase domains in the mitochondrial protein Miro Landahl, EC, Focia, PJ, Klosowiak, JL, Freymann, DM, Rice, SE, Chakravarthy, S	EMBO Rep	2013
28610953	A thirty-year quest for a role of R-Ras in cancer: from an oncogene to a multitasking GTPase Liu, WN, Yan, M, Chan, AM	Cancer Lett.	2017
23732472	Mitochondrial trafficking in neurons Schwarz, TL	Cold Spring Harb Perspect Biol	2013
16212495	Rho GTPases: biochemistry and biology Hall, A, Jaffe, AB	Annu Rev Cell Dev Biol	2005
29364559	A role for Mitochondrial Rho GTPase 1 (MIRO1) in motility and membrane dynamics of peroxisomes Schrader, TA, Schrader, M, Metz, J, Passmore, JB, Ribeiro, D, Costello, JL, Castro, IG, Richards, DM, Gouveia, A	Traffic	2018
31894645	Peroxisomal fission is modulated by the mitochondrial Rho-GTPases, Miro1 and Miro2 Covill-Cooke, C, Lopez-Domenech, G, Birsa, N, Kittler, JT, Toncheva, VS, Drew, J	EMBO Rep	2020
17035353	Evolution of the Rho family of ras-like GTPases in eukaryotes Fort, P, Faure, S, Vignal, E, Boureux, A	Mol Biol Evol	2007
26707701	Miro sculpts mitochondrial dynamics in neuronal health and disease Devine, MJ, Birsa, N, Kittler, JT	Neurobiol. Dis.	2016
29222186	New splicing variants of mitochondrial Rho GTPase-1 (Miro1) transport peroxisomes Okumoto, K, Nagata, A, Toyama, R, Ono, T, Shimomura, A, Fujiki, Y	J Cell Biol	2018