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Aberrant regulation of mitotic exit in cancer due to RB1 defects
Stable Identifier
R-HSA-9687136
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Disease (Homo sapiens)
Diseases of mitotic cell cycle (Homo sapiens)
Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
Aberrant regulation of mitotic exit in cancer due to RB1 defects (Homo sapiens)
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RB1 regulates mitotic exit by acting on SKP2, a component of the SCF E3 ubiquitin ligase complex. RB1 facilitates degradation of SKP2 by the anaphase promoting complex/cyclosome (APC/C), thus preventing SKP2-mediated degradation of the cyclin-dependent kinase inhibitor CDKN1B (p27Kip1). RB1-dependent accumulation of p27Kip1 plays an important role in mitotic exit and RB1-mediated tumor suppression (reviewed by Dyson 2016).
Literature References
PubMed ID
Title
Journal
Year
27401552
RB1: a prototype tumor suppressor and an enigma
Dyson, NJ
Genes Dev.
2016
Participants
Events
Defective RB1 does not form a complex with SKP2 and FZR1
(Homo sapiens)
Participates
as an event of
Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
Cross References
BioModels Database
BIOMD0000000187
,
BIOMD0000000186
,
BIOMD0000000954
Authored
Orlic-Milacic, M (2020-05-07)
Reviewed
Dick, FA (2020-05-17)
Created
Orlic-Milacic, M (2020-05-06)
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