A notable success of this search is a combination treatment, Paxlovid (NCT04960202), involving ritonavir, an inhibitor of CYP3A4 and CYP2B6 oxidoreductases, and nirmatrelvir, an inhibitor of SARS-CoV-2 3CLp protease, to block steps in maturation of viral replicase proteins (Hashemian et al. 2023).
Rosa, SGV, Santos, WC
Mirzaei, H, Bannazadeh Baghi, H, Sadri Nahand, J, Taghizadieh, M, Hashemian, SMR, Sheida, A, Hamblin, MR, Memar, MY, Asemi, Z
Harrison, C
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