Diseases of mitotic cell cycle

Stable Identifier
R-HSA-9675126
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
Diseases of mitotic cell cycle
Click the image above or here to open this pathway in the Pathway Browser
Diseases of mitotic cell cycle are caused by mutations in cell cycle regulators (Collins and Garrett 2005, Diaz-Moralli et al. 2013), such as retinoblastoma protein RB1 (Classon and Harlow 2002), as well as proteins involved in telomere maintenance, such as ATRX and DAXX (Sarek et al. 2015). These diseases mainly include different types of cancer, hereditary syndromes such as dyskeratosis congenita that may predispose affected patients to cancer, and neurodegenerative diseases (Webber et al. 2005).
Literature References
PubMed ID Title Journal Year
23356980 Targeting cell cycle regulation in cancer therapy

Cascante, M, Miranda, A, Tarrado-Castellarnau, M, Diaz-Moralli, S

Pharmacol. Ther. 2013
15964238 Targeting the cell division cycle in cancer: CDK and cell cycle checkpoint kinase inhibitors

Collins, I, Garrett, MD

Curr Opin Pharmacol 2005
26581521 Molecular basis of telomere dysfunction in human genetic diseases

Marzec, P, Boulton, SJ, Margalef, P, Sarek, G

Nat. Struct. Mol. Biol. 2015
15936057 The cell cycle in Alzheimer disease: a unique target for neuropharmacology

Zhu, X, Marlatt, MW, Webber, KM, Morelli, L, Casadesus, G, Prat, MI, Smith, MA, Raina, AK, Perry, G

Mech. Ageing Dev. 2005
12459729 The retinoblastoma tumour suppressor in development and cancer

Classon, M, Harlow, E

Nat. Rev. Cancer 2002
Participants
Events
Participates
as an event of
Disease
Name Identifier Synonyms
disease of cellular proliferation DOID:14566 neoplasm, cell process disease
Authored
Orlic-Milacic, M  (2020-05-07)
Reviewed
Matthews, L  (2020-05-27)
Created
Orlic-Milacic, M  (2020-01-31)
Cite Us!