Reactome | BMG, BDG translocates from ER lumen to cytosol

BMG, BDG translocates from ER lumen to cytosol

Stable Identifier

R-HSA-9661446

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum lumen, endoplasmic reticulum membrane

ReviewStatus

5/5

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BMG, BDG translocates from ER lumen to cytosol

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To be excreted from the cell, mono- and di-glucuronated bilirubin (BMG, BDG respectively) translocate from the ER lumen to the cytosol. Glucuronated bilirubin is a much more hydrophilic substance than bilirubin so the assumption is some form of active transport is required for this translocation. No transporter has been identified yet but tentatively, we assign the name bilirubin glucuronide efflux transporter (BGET) (Erlinger et al. 2014, Rowland et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
23500526	The UDP-glucuronosyltransferases: their role in drug metabolism and detoxification Miners, JO, Rowland, A, Mackenzie, PI	Int. J. Biochem. Cell Biol.	2013
24704527	Inherited disorders of bilirubin transport and conjugation: new insights into molecular mechanisms and consequences Erlinger, S, Dhumeaux, D, Arias, IM	Gastroenterology	2014