ALB binds extracellular heme

Stable Identifier
R-HSA-9661419
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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ALB binds extracellular heme
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Circulating free heme is cytotoxic. Binding of albumin (ALB) to heme protects cells from this potential toxicity. Heme transported out of cells by ABCG2 may be directly transferred from the transport protein onto HSA (human serum albumin (Desuzinges-Mandon et al. 2010), while heme transported by FLVCR1-1 may initially associated with lipoproteins before transfer to HSA (De Simone et al. 2023).
Literature References
PubMed ID Title Journal Year
36979511 Heme Scavenging and Delivery: The Role of Human Serum Albumin

Ruberto, TF, Ascenzi, P, De Simone, G, Varricchio, R, di Masi, A

Biomolecules 2023
20705604 ABCG2 transports and transfers heme to albumin through its large extracellular loop

Huché, F, Martinez, L, Di Pietro, A, Arnaud, O, Falson, P, Desuzinges-Mandon, E

J. Biol. Chem. 2010
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Orthologous Events
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Authored
Jassal, B  (2019-09-16)
Reviewed
D'Eustachio, P  (2019-10-03)
Created
Jassal, B  (2019-09-16)
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