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C1QBP [cytosol]
Stable Identifier
R-HSA-9645690
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
C1q binding protein, p32
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of programmed cell death (Homo sapiens)
Defective Intrinsic Pathway for Apoptosis (Homo sapiens)
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function (Homo sapiens)
p14ARF mutants do not bind C1QBP (Homo sapiens)
C1QBP homotrimer [cytosol] (Homo sapiens)
C1QBP [cytosol] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Apoptotic factor-mediated response (Homo sapiens)
C1QBP promotes translocation of p14ARF to the mitochondrial matrix (Homo sapiens)
p14ARF:C1QBP [cytosol] (Homo sapiens)
C1QBP homotrimer [cytosol] (Homo sapiens)
C1QBP [cytosol] (Homo sapiens)
p14ARF binds C1QBP (Homo sapiens)
C1QBP homotrimer [cytosol] (Homo sapiens)
C1QBP [cytosol] (Homo sapiens)
p14ARF:C1QBP [cytosol] (Homo sapiens)
C1QBP homotrimer [cytosol] (Homo sapiens)
C1QBP [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RHOA GTPase cycle (Homo sapiens)
RHOA binds effectors at the plasma membrane (Homo sapiens)
RHOA plasma membrane effectors [cytosol] (Homo sapiens)
C1QBP [cytosol] (Homo sapiens)
RHOA:GTP:cytosolic RHOA effectors [plasma membrane] (Homo sapiens)
RHOA plasma membrane effectors [cytosol] (Homo sapiens)
C1QBP [cytosol] (Homo sapiens)
RHOC GTPase cycle (Homo sapiens)
RHOC binds effectors at the plasma membrane (Homo sapiens)
RHOC effectors [cytosol] (Homo sapiens)
C1QBP [cytosol] (Homo sapiens)
RHOC:GTP:RHOC effectors [plasma membrane] (Homo sapiens)
RHOC effectors [cytosol] (Homo sapiens)
C1QBP [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q07021 C1QBP
Gene Names
C1QBP, GC1QBP, HABP1, SF2P32
Chain
transit peptide:1-73, chain:74-282
Reference Genes
BioGPS Gene:708 C1QBP
COSMIC (genes):C1QBP C1QBP
CTD Gene:708 C1QBP
dbSNP Gene:708 C1QBP
ENSEMBL:ENSG00000108561 C1QBP
ENSEMBL_homo_sapiens_GENE:ENSG00000108561.8 C1QBP
HGNC:1243 C1QBP
KEGG Gene (Homo sapiens):708 C1QBP
Monarch:708 C1QBP
NCBI Gene:708 C1QBP
OMIM:601269 C1QBP
UCSC:Q07021 C1QBP
Reference Transcript
RefSeq:NM_001212.3 C1QBP
Other Identifiers
11757434_a_at
16840284
208910_PM_s_at
208910_s_at
214214_PM_s_at
214214_s_at
3378512
3378518
3742709
3742710
3742711
3742713
3742715
3742717
3742720
3742723
3742724
3742725
37668_at
708
8011850
A_23_P370434
GO:0000122
GO:0001849
GO:0002250
GO:0002376
GO:0003714
GO:0003723
GO:0003729
GO:0005515
GO:0005540
GO:0005576
GO:0005634
GO:0005730
GO:0005737
GO:0005739
GO:0005759
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006397
GO:0006915
GO:0006955
GO:0006958
GO:0007155
GO:0008134
GO:0008380
GO:0009986
GO:0012501
GO:0016020
GO:0016071
GO:0022414
GO:0023052
GO:0030449
GO:0030984
GO:0031690
GO:0032689
GO:0032695
GO:0039534
GO:0039536
GO:0042254
GO:0042256
GO:0043065
GO:0043226
GO:0043491
GO:0045087
GO:0045785
GO:0048025
GO:0048856
GO:0048870
GO:0050687
GO:0051897
GO:0070131
GO:0090023
GO:0097177
GO:0098542
GO:0140053
GO:0140110
GO:1900026
GO:1901165
GO:2000510
HMNXSV003013218
Hs.78614.3.A1_3p_a_at
ILMN_1668996
M69039_at
PH_hs_0004535
PH_hs_0035931
TC17001056.hg
TC17002457.hg
Participates
as a candidate of
RHOA plasma membrane effectors [cytosol] (Homo sapiens)
RHOC effectors [cytosol] (Homo sapiens)
as a component of
C1QBP homotrimer [cytosol] (Homo sapiens)
Other forms of this molecule
C1QBP [plasma membrane]
C1QBP [mitochondrial matrix]
Inferred To
MAM33 [cytosol]
(Saccharomyces cerevisiae)
P32 [cytosol]
(Drosophila melanogaster)
c1qbp [cytosol]
(Xenopus tropicalis)
C1qbp [cytosol]
(Mus musculus)
C1qbp [cytosol]
(Rattus norvegicus)
cri-3 [cytosol]
(Caenorhabditis elegans)
C1QBP [cytosol]
(Bos taurus)
C1QBP [cytosol]
(Canis familiaris)
C1QBP [cytosol]
(Gallus gallus)
C1QBP [cytosol]
(Schizosaccharomyces pombe)
C1QBP [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_001203.1
OpenTargets
ENSG00000108561
HPA
ENSG00000108561-C1QBP
GeneCards
Q07021
Ensembl
ENSG00000108561
,
ENSP00000225698
,
ENST00000225698
PRO
Q07021
Pharos - Targets
Q07021
PDB
7TE3
,
1P32
,
3RPX
,
6SZW
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P67809 YBX1
5
p-S32,S36-YBX1 [nucleoplasm]
(R-HSA-9733227)
p-S32,S36-YBX1 [cytosol]
(R-HSA-9736837)
YBX1 [cytosol]
(R-HSA-9736840)
YBX1 [nucleoplasm]
(R-HSA-72041)
YBX1 [extracellular region]
(R-HSA-9017791)
0.85
11
UniProt:P04004 VTN
1
VTN [extracellular region]
(R-HSA-215971)
0.702
9
UniProt:Q05513 PRKCZ
5
p-T410,T563-PRKCZ [cytosol]
(R-HSA-5218698)
PRKCZ [cytosol]
(R-HSA-58218)
PRKCZ [cell junction]
(R-HSA-2134483)
p-T410-PRKCZ [cytosol]
(R-HSA-437181)
pS, p-T410-PRKCZ [cytosol]
(R-HSA-9632824)
0.669
4
UniProt:Q12948 FOXC1
1
FOXC1 [nucleoplasm]
(R-HSA-3927815)
0.61
6
UniProt:Q7Z434 MAVS
2
MAVS [mitochondrial outer membrane]
(R-HSA-913730)
K48polyUb-MAVS [mitochondrial outer membrane]
(R-HSA-983463)
0.589
5
UniProt:Q08211 DHX9
3
DHX9 [cytosol]
(R-HSA-847700)
p-DHX9 [cytosol]
(R-HSA-9836168)
DHX9 [nucleoplasm]
(R-HSA-53517)
0.564
2
UniProt:Q8N726 CDKN2A
12
p14ARF [nucleoplasm]
(R-HSA-1629813)
p14ARF [cytosol]
(R-HSA-9645669)
p14ARF [mitochondrial matrix]
(R-HSA-9645695)
p14ARF R98L;R99S [cytosol]
(R-HSA-9645730)
p14ARF R82C [cytosol]
(R-HSA-9645750)
p14ARF R90H [cytosol]
(R-HSA-9645755)
p14ARF R88Q [cytosol]
(R-HSA-9645754)
p14ARF R87C [cytosol]
(R-HSA-9645759)
p14ARF R81G [cytosol]
(R-HSA-9645741)
p14ARF R98Q [cytosol]
(R-HSA-9645757)
p14ARF R99C [cytosol]
(R-HSA-9645756)
p14ARF V22Pfs*46 [cytosol]
(R-HSA-9646285)
0.556
3
UniProt:P01042 KNG1
8
KNG1(19-644) [platelet alpha granule lumen]
(R-HSA-139864)
p-KNG1 [endoplasmic reticulum lumen]
(R-HSA-8956939)
KNG1 [endoplasmic reticulum lumen]
(R-HSA-8956767)
KNG1(19-380) [plasma membrane]
(R-HSA-158245)
KNG1(390-644) [plasma membrane]
(R-HSA-158279)
KNG1(19-644) [plasma membrane]
(R-HSA-158269)
KNG1(19-644) [extracellular region]
(R-HSA-158125)
Bradykinin [extracellular region]
(R-HSA-158344)
0.544
4
UniProt:P50281 MMP14
3
MMP14 [plasma membrane]
(R-HSA-1442472)
MMP14(21-582) [Golgi lumen]
(R-HSA-1604689)
MMP14 [Golgi lumen]
(R-HSA-1604724)
0.544
2
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.527
4
UniProt:Q86V81 ALYREF
2
ALYREF [nucleoplasm]
(R-HSA-156649)
ALYREF [cytosol]
(R-HSA-158482)
0.527
2
UniProt:P02647 APOA1
11
APOA1(25-266) [secretory granule lumen]
(R-HSA-350761)
APOA1(25-267) [cytosol]
(R-HSA-2395781)
APOA1(25-267) [early endosome]
(R-HSA-2429641)
APOA1(25-267) [endoplasmic reticulum lumen]
(R-HSA-174640)
APOA1(19-266) [extracellular region]
(R-HSA-264771)
APOA1(25-266) [plasma membrane]
(R-HSA-216742)
APOA1(25-266) [endocytic vesicle lumen]
(R-HSA-2239460)
Variant apolipoprotein AI [extracellular region]
(R-HSA-976865)
p-APOA1 [endoplasmic reticulum lumen]
(R-HSA-8957081)
APOA1 [endoplasmic reticulum lumen]
(R-HSA-8956724)
APOA1(25-266) [extracellular region]
(R-HSA-174720)
0.499
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
13
UniProt:P00734 F2
11
prothrombin (factor II) propeptide [Golgi lumen]
(R-HSA-159759)
10xCbxE-F2(44-622) [Golgi lumen]
(R-HSA-159845)
10xCbxE-F2(25-622) [Golgi lumen]
(R-HSA-159841)
10xCbxE-F2(25-622) [endoplasmic reticulum lumen]
(R-HSA-159800)
F2(25-622) [endoplasmic reticulum lumen]
(R-HSA-159739)
thrombin heavy chain [plasma membrane]
(R-HSA-140809)
thrombin light chain [plasma membrane]
(R-HSA-140810)
10xCbxE-F2(44-327) [extracellular region]
(R-HSA-140786)
10xCbxE-F2(44-622) [extracellular region]
(R-HSA-140674)
thrombin heavy chain [extracellular region]
(R-HSA-140589)
thrombin light chain [extracellular region]
(R-HSA-140598)
0.462
3
UniProt:P01008 SERPINC1
8
SERPINC1(33-425) [plasma membrane]
(R-HSA-140815)
SERPINC1(426-464) [plasma membrane]
(R-HSA-140816)
SERPINC1 [plasma membrane]
(R-HSA-140792)
SERPINC1 [extracellular region]
(R-HSA-140807)
p-SERPINC1 [endoplasmic reticulum lumen]
(R-HSA-8957069)
SERPINC1 [endoplasmic reticulum lumen]
(R-HSA-8956773)
SERPINC1(33-425) [extracellular region]
(R-HSA-140814)
SERPINC1(426-464) [extracellular region]
(R-HSA-140817)
0.462
3
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